Areas under peripheral pulse waves: a potential marker of atherosclerotic changes
Peltokangas, Mikko; Verho, Jarmo; Mattila, Ville M; Romsi, Pekka; Vehkaoja, Antti; Lekkala, Jukka; Oksala, Niku (2018)
https://urn.fi/urn:nbn:fi:tty-201801181111
Kuvaus
Tiivistelmä
OBJECTIVE: In this study, we propose a method for finding : atherosclerotic changes based on the ratios of areas under peripheral arterial pulse : wave (PW) contours and analyze its performance.
APPROACH: The PW signals : were recorded with force sensors and photoplethysmographic sensors from ankle, : wrist, cubital fossa, index finger and second toe from 30 atherosclerotic patients : and 52 control subjects. In addition, day-to-day repeatability of the method : was studied with 10 test subjects examined on 3 different days. The ratios of : areas under the PWs were computed and the results were evaluated by means : of receiver operating characteristic (ROC) analysis, intra-class correlation (ICC) : coefficient and multiple linear regression analysis.
MAIN RESULTS: Areas under : ROC curves of 0.802-0.906 were found for different area ratios having statistically : significant differences between the atheroslerotic group and control groups. ICCs : over 0.80 were found widely for the beat-by-beat analyzed data and over 0.95 for : the data based on the averages over different numbers of PWs. Multiple linear : regression analysis showed linear dependence between the area ratios and age : and the diagnosis of atherosclerosis.
SIGNIFICANCE: Our findings may facilitate : development of novel diagnostic approaches and preventive strategies against : cardiovascular disorders. However, further studies are needed to confirm the : results. The presented study demonstrates the potential of arterial PW analysis : in finding vascular abnormalities. .
Kokoelmat
- TUNICRIS-julkaisut [19817]