Multicomponent Petasis-borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies
Neto, Íris; Andrade, Joana; Pinto Reis, Catarina; Salunke, Jagadish K.; Priimagi, Arri; R. Candeias, Nuno; Rijo, Patricia (2016-09)
Pinto Reis, Catarina
Salunke, Jagadish K.
R. Candeias, Nuno
09 / 2016
Julkaisun pysyvä osoite on
In this work we report the antibacterial activity of alkylaminophenols. A series of such compounds was prepared by a multicomponent Petasis-borono Mannich reaction starting from salicylaldehyde and its derivatives. The obtained compounds were tested against a large panel of microorganisms, Gram-positive and Gram-negative bacteria, and a yeast. Among the several tertiary amine derivatives tested, indoline-derived aminophenols containing a nitro group at the para-phenol position showed considerable activity against bacteria tested with minimal inhibitory concentrations as low as 1.36 μm against Staphyloccocus aureus and Mycobacterium smegmatis. Cytotoxicity of the new para-nitrophenol derivatives was observed only at concentrations much higher than those required for antibacterial activity.
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