"Ylä-Herttuala, Seppo" - Selaus tekijän mukaan TUNICRIS-julkaisut

Viitteet 1-7 / 7

    • Caridac vein retroinjections provide an efficient approach for global left ventricular gene transfer with adenovirus and adeno-associated virus 

      Lampela, Jaakko; Pajula, Juho; Järveläinen, Niko; Siimes, Satu; Laham-Karam, Nihay; Kivelä, Antti; Mushimiyimana, Isidore; Nurro, Jussi; Hartikainen, Juha; Ylä-Herttuala, Seppo (01 / 2024)
      article
      Heart failure (HF) is a major burden worldwide, and new therapies are urgently needed. Gene therapy is a promising new approach to treat myocardial diseases. However, current cardiac gene delivery methods for producing ...

    • Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation 

      Keränen, Sara; Suutarinen, Santeri; Mallick, Rahul; Laakkonen, Johanna P.; Guo, Diana; Pawlikowska, Ludmila; Jahromi, Behnam Rezai; Rauramaa, Tuomas; Ylä-Herttuala, Seppo; Marchuk, Doug; Krings, Timo; Koivisto, Timo; Lawton, Michael; Radovanovic, Ivan; Kim, Helen; Faughnan, Marie E.; Frösen, Juhana (2021)
      article
      Background: Brain arteriovenous malformations (bAVM) may rupture causing disability or death. BAVM vessels are characterized by abnormally high flow that in general triggers expansive vessel remodeling mediated by ...

    • Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures 

      Örd, Tiit; Lönnberg, Tapio; Nurminen, Valtteri; Ravindran, Aarthi; Niskanen, Henri; Kiema, Miika; Õunap, Kadri; Maria, Maleeha; Moreau, Pierre R.; Mishra, Pashupati P.; Palani, Senthil; Virta, Jenni; Liljenbäck, Heidi; Aavik, Einari; Roivainen, Anne; Ylä-Herttuala, Seppo; Laakkonen, Johanna P.; Lehtimäki, Terho; Kaikkonen, Minna U. (05 / 2023)
      article
      Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is explained by genetic factors. Advanced insights into the genetic basis of CAD require deeper understanding of the contributions of different ...

    • Lentivirus vector-mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain 

      Ahmad, Farizan; Hyvärinen, Anna; Pirinen, Agnieszka; Olsson, Venla; Rummukainen, Jaana; Immonen, Arto; Närväinen, Johanna; Tuunanen, Pasi; Liimatainen, Timo; Kärkkäinen, Virve; Koistinaho, Jari; Ylä-Herttuala, Seppo (04 / 2021)
      article
      Translation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for ...

    • PeptiCHIP : A Microfluidic Platform for Tumor Antigen Landscape Identification 

      Feola, Sara; Haapala, Markus; Peltonen, Karita; Capasso, Cristian; Martins, Beatriz; Antignani, Gabriella; Federico, Antonio; Pietiäinen, Vilja; Chiaro, Jacopo; Feodoroff, Michaela; Russo, Salvatore; Rannikko, Antti; Fusciello, Manlio; Koskela, Satu; Partanen, Jukka; Hamdan, Firas; Tähkä, Sari M.; Ylösmäki, Erkko; Greco, Dario; Grönholm, Mikaela; Kekarainen, Tuija; Eshaghi, Masoumeh; Gurvich, Olga L.; Ylä-Herttuala, Seppo; Rui, Rui M.; Lehtiö, Janne; Sikanen, Tiina M.; Cerullo, Vincenzo (2021)
      article
      Identification of HLA class I ligands from the tumor surface (ligandome or immunopeptidome) is essential for designing T-cell mediated cancer therapeutic approaches. However, the sensitivity of the process for isolating ...

    • Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence 

      Kopra, Kari; Hassan, Nazia; Vuorinen, Emmiliisa; Valtonen, Salla; Mahran, Randa; Habib, Huda; Jalkanen, Pinja; Susi, Petri; Hytönen, Vesa; Hankaniemi, Minna; Ylä-Herttuala, Seppo; Kakkola, Laura; Peurla, Markus; Härmä, Harri (06 / 2022)
      article
      Viruses play a major role in modern society and create risks from global pandemics and bioterrorism to challenges in agriculture. Virus infectivity assays and genome copy number determination methods are often used to ...

    • Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta 

      Kiema, Miika; Sarin, Jaakko K.; Kauhanen, S. Petteri; Torniainen, Jari; Matikka, Hanna; Luoto, Emma Sofia; Jaakkola, Pekka; Saari, Petri; Liimatainen, Timo; Vanninen, Ritva; Ylä-Herttuala, Seppo; Hedman, Marja; Laakkonen, Johanna P. (07.07.2022)
      article
      Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues ...