"Wechsler, Michael E." - Selaus tekijän mukaan TUNICRIS-julkaisut

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    • Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma 

      Porsbjerg, Celeste M.; Townend, John; Bergeron, Celine; Christoff, George C.; Katsoulotos, Gregory P.; Larenas-Linnemann, Désirée; Tran, Trung N.; Al-Lehebi, Riyad; Bosnic-Anticevich, Sinthia Z.; Busby, John; Hew, Mark; Kostikas, Konstantinos; Papadopoulos, Nikolaos G.; Pfeffer, Paul E.; Popov, Todor A.; Rhee, Chin Kook; Sadatsafavi, Mohsen; Tsai, Ming Ju; Ulrik, Charlotte Suppli; Al-Ahmad, Mona; Altraja, Alan; Beastall, Aaron; Bulathsinhala, Lakmini; Carter, Victoria; Cosio, Borja G.; Fletton, Kirsty; Hansen, Susanne; Heaney, Liam G.; Hubbard, Richard B.; Kuna, Piotr; Murray, Ruth B.; Nagano, Tatsuya; Pini, Laura; Cano Rosales, Diana Jimena; Schleich, Florence; Wechsler, Michael E.; Amaral, Rita; Bourdin, Arnaud; Brusselle, Guy G.; Chen, Wenjia; Chung, Li Ping; Denton, Eve; Fonseca, Joao A.; Hoyte, Flavia; Jackson, David J.; Katial, Rohit; Kirenga, Bruce J.; Koh, Mariko Siyue; Ławkiedraj, Agnieszka; Lehtimäki, Lauri; Liew, Mei Fong; Mahboub, Bassam; Martin, Neil; Menzies-Gow, Andrew N.; Pang, Pee Hwee; Papaioannou, Andriana I.; Patel, Pujan H.; Perez-De-Llano, Luis; Peters, Matthew J.; Ricciardi, Luisa; Rodríguez-Cáceres, Bellanid; Solarte, Ivan; Tay, Tunn Ren; Torres-Duque, Carlos A.; Wang, Eileen; Zappa, Martina; Abisheganaden, John; Assing, Karin Dahl; Costello, Richard W.; Gibson, Peter G.; Heffler, Enrico; Máspero, Jorge; Nicola, Stefania; Perng, Diahn Warng; Puggioni, Francesca; Salvi, Sundeep; Sheu, Chau Chyun; Sirena, Concetta; Taillé, Camille; Tan, Tze Lee; Bjermer, Leif; Canonica, Giorgio Walter; Iwanaga, Takashi; Jiménez-Maldonado, Libardo; Taube, Christian; Brussino, Luisa; Price, David B. (2024)
      article
      Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical ...

    • Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy 

      Chen, Wenjia; Sadatsafavi, Mohsen; Tran, Trung N.; Murray, Ruth B.; Wong, Chong Boon Nigel; Ali, Nasloon; Ariti, Cono; Gil, Esther Garcia; Newell, Anthony; Alacqua, Marianna; Al-Ahmad, Mona; Altraja, Alan; Al-Lehebi, Riyad; Bhutani, Mohit; Bjermer, Leif; Bjerrum, Anne Sofie; Bourdin, Arnaud; Bulathsinhala, Lakmini; Von Bülow, Anna; Busby, John; Canonica, Giorgio Walter; Carter, Victoria; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; Fitzgerald, J. Mark; Fonseca, João A.; Ha Yoo, Kwang; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Iwanaga, Takashi; Jackson, David J.; Jones, Rupert C.; Koh, Mariko Siyue; Kuna, Piotr; Larenas-Linnemann, Désirée; Lehmann, Sverre; Lehtimäki, Lauri A.; Lyu, Juntao; Mahboub, Bassam; Maspero, Jorge; Menzies-Gow, Andrew N.; Sirena, Concetta; Papadopoulos, Nikolaos; Papaioannou, Andriana I.; De Llano, Luis Pérez; Perng, Diahn Warng; Peters, Matthew; Pfeffer, Paul E.; Porsbjerg, Celeste M.; Popov, Todor A.; Rhee, Chin Kook; Salvi, Sundeep; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Ulrik, Charlotte S.; Won Ra, Seung; Wang, Eileen; Wechsler, Michael E.; Price, David B. (2022)
      article
      <p>Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients ...

    • Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both 

      Pfeffer, Paul E.; Ali, Nasloon; Murray, Ruth; Ulrik, Charlotte; Tran, Trung N.; Maspero, Jorge; Peters, Matthew; Christoff, George C.; Sadatsafavi, Mohsen; Torres-Duque, Carlos A.; Altraja, Alan; Lehtimäki, Lauri; Papadopoulos, Nikolaos G; Salvi, Sundeep; Costello, Richard W.; Cushen, Breda; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Larenas-Linnemann, Désirée; Kuna, Piotr; Fonseca, João A.; Al-Lehebi, Riyad; Rhee, Chin Kook; Perez-de-Llano, Luis; Perng Steve, Diahn Warng; Mahboub, Bassam; Wang, Eileen; Goh, Celine; Lyu, Juntao; Newell, Anthony; Alacqua, Marianna; Belevskiy, Andrey S.; Bhutani, Mohit; Bjermer, Leif; Bjornsdottir, Unnur; Bourdin, Arnaud; Bulow, Anna von; Busby, John; Canonica, Giorgio Walter; Cosio, Borja G.; Dorscheid, Delbert R.; Muñoz-Esquerre, Mariana; FitzGerald, J. Mark; Gil, Esther Garcia; Gibson, Peter G.; Heaney, Liam G.; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Jackson, David J.; Koh, Mariko Siyue; Ko, Hsin Kuo Bruce; Lee, Jae Ha; Lehmann, Sverre; Chaves Loureiro, Cláudia; Lúðvíksdóttir, Dóra; Menzies-Gow, Andrew N.; Mitchell, Patrick; Papaioannou, Andriana I.; Popov, Todor A.; Porsbjerg, Celeste M.; Salameh, Laila; Sirena, Concetta; Taillé, Camille; Taube, Christian; Tohda, Yuji; Wechsler, Michael E.; Price, David B. (03 / 2023)
      article
      <p>Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult ...

    • Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort 

      Heaney, Liam G.; Perez de Llano, Luis; Al-Ahmad, Mona; Backer, Vibeke; Busby, John; Canonica, Giorgio Walter; Christoff, George C.; Cosio, Borja G.; FitzGerald, J. Mark; Heffler, Enrico; Iwanaga, Takashi; Jackson, David J.; Menzies-Gow, Andrew N.; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Pfeffer, Paul E.; Popov, Todor A.; Porsbjerg, Celeste M.; Rhee, Chin Kook; Sadatsafavi, Mohsen; Tohda, Yuji; Wang, Eileen; Wechsler, Michael E.; Alacqua, Marianna; Altraja, Alan; Bjermer, Leif; Björnsdóttir, Unnur S.; Bourdin, Arnaud; Brusselle, Guy G.; Buhl, Roland; Costello, Richard W.; Hew, Mark; Koh, Mariko Siyue; Lehmann, Sverre; Lehtimäki, Lauri; Peters, Matthew; Taillé, Camille; Taube, Christian; Tran, Trung N.; Zangrilli, James; Bulathsinhala, Lakmini; Carter, Victoria A.; Chaudhry, Isha; Eleangovan, Neva; Hosseini, Naeimeh; Kerkhof, Marjan; Murray, Ruth B.; Price, Chris A.; Price, David B. (09 / 2021)
      article
      <p>Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of ...

    • Exploring Definitions and Predictors of Response to Biologics for Severe Asthma 

      Scelo, Ghislaine; Tran, Trung N.; Le, Tham T.; Fagerås, Malin; Dorscheid, Delbert; Busby, John; Al-Ahmad, Mona; Al-Lehebi, Riyad; Altraja, Alan; Beastall, Aaron; Bergeron, Celine; Bjermer, Leif; Bjerrum, Anne S.; Cano-Rosales, Diana Jimena; Canonica, Giorgio Walter; Carter, Victoria; Charriot, Jeremy; Christoff, George C.; Cosio, Borja G.; Denton, Eve; Fernandez-Sanchez, Maria Jose; Fonseca, João A.; Gibson, Peter G.; Goh, Celine; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Iwanaga, Takashi; Katial, Rohit; Koh, Mariko S.; Kuna, Piotr; Larenas-Linnemann, Désirée; Lehtimäki, Lauri; Mahboub, Bassam; Martin, Neil; Matsumoto, Hisako; Menzies-Gow, Andrew N.; Papadopoulos, Nikolaos G.; Patel, Pujan; Perez-De-Llano, Luis; Peters, Matthew; Pfeffer, Paul E.; Popov, Todor A.; Porsbjerg, Celeste M.; Rhee, Chin K.; Sadatsafavi, Mohsen; Taillé, Camille; Torres-Duque, Carlos A.; Tsai, Ming Ju; Ulrik, Charlotte S.; Upham, John W.; von Bülow, Anna; Wang, Eileen; Wechsler, Michael E.; Price, David B. (2024)
      article
      Background: Biologic effectiveness is often assessed as response, a term that eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. Objective: To explore definitions ...

    • Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults 

      Perez-De-Llano, Luis; Scelo, Ghislaine; Tran, Trung N.; Le, Tham T.; Fagerås, Malin; Cosio, Borja G.; Peters, Matthew; Pfeffer, Paul E.; Al-Ahmad, Mona; Al-Lehebi, Riyad O.; Altraja, Alan; Bergeron, Celine; Bjermer, Leif H.; Bjerrum, Anne S.; Bulathsinhala, Lakmini; Busby, John; Cano Rosales, Diana J.; Canonica, Giorgio W.; Carter, Victoria A.; Charriot, Jeremy; Christoff, George C.; Denton, Eve J.; Dorscheid, Delbert R.; Fernandez Sanchez, Maria J.; Fonseca, João A.; Gibson, Peter G.; Goh, Celine Y.Y.; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Iwanaga, Takashi; Katial, Rohit; Koh, Mariko S.; Kuna, Piotr; Larenas-Linnemann, Desir ee E.S.; Lehtimaki, Lauri; Mahboub, Bassam; Martin, Neil; Matsumoto, Hisako; Menzies-Gow, Andrew N.; Papadopoulos, Nikolaos G.; Popov, Todor A.; Porsbjerg, Celeste M.; Patel, Pujan; Rhee, Chin K.; Sadatsafavi, Mohsen; Taille, Camille; Torres-Duque, Carlos A.; Tsai, Ming Ju; Ulrik, Charlotte S.; Upham, John W.; von Bulow, Anna; Wang, Eileen; Wechsler, Michael E.; Price, David B. (10 / 2024)
      article
      Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify ...

    • Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma 

      Porsbjerg, Celeste M.; Menzies-Gow, Andrew N.; Tran, Trung N.; Murray, Ruth B.; Unni, Bindhu; Audrey Ang, Shi Ling; Alacqua, Marianna; Al-Ahmad, Mona; Al-Lehebi, Riyad; Altraja, Alan; Belevskiy, Andrey S.; Björnsdóttir, Unnur S.; Bourdin, Arnaud; Busby, John; Canonica, G. Walter; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; FitzGerald, J. Mark; Fonseca, João A.; Hansen, Susanne; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Iwanaga, Takashi; Jackson, Daniel J.; Kocks, Janwillem W.H.; Kallieri, Maria; Bruce Ko, Hsin Kuo; Koh, Mariko Siyue; Larenas-Linnemann, Désirée; Lehtimäki, Lauri A.; Loukides, Stelios; Lugogo, Njira; Maspero, Jorge; Papaioannou, Andriana I.; Perez-de-Llano, Luis; Pitrez, Paulo Márcio; Popov, Todor A.; Rasmussen, Linda M.; Rhee, Chin Kook; Sadatsafavi, Mohsen; Schmid, Johannes; Siddiqui, Salman; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Ulrik, Charlotte; Upham, John W.; Wang, Eileen; Wechsler, Michael E.; Bulathsinhala, Lakmini; Carter, Victoria; Chaudhry, Isha; Eleangovan, Neva; Hosseini, Naeimeh; Rowlands, Mari Anne; Price, David B.; van Boven, Job F.M. (2022)
      reviewarticle
      <p>Background: Regulatory bodies have approved five biologics for severe asthma. However, regional differences in accessibility may limit the global potential for personalized medicine. Objective: To compare global ...

    • Impact of Inititing Biologics in Patients With Severe Asthma on Long-term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry 

      Chen, Wenjia; Tran, Trung N.; Sadatsafavi, Mohsen; Murray, Ruth; Wong, Nigel Chong Boon; Ali, Nasloon; Ariti, Con; Bulathsinhala, Lakmini; Gil, Esther Garcia; FitzGerald, J. Mark; Alacqua, Marianna; Al-Ahmad, Mona; Altraja, Alan; Al-Lehebi, Riyad; Bhutani, Mohit; Bjermer, Leif; Bjerrum, Anne Sofie; Bourdin, Arnaud; von Bülow, Anna; Busby, John; Canonica, Giorgio Walter; Carter, Victoria; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; Fonseca, João A.; Gibson, Peter G.; Yoo, Kwang Ha; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Iwanaga, Takashi; Jackson, David J.; Jones, Rupert C.; Koh, Mariko Siyue; Kuna, Piotr; Larenas-Linnemann, Désirée; Lehmann, Sverre; Lehtimäki, Lauri; Lyu, Juntao; Mahboub, Bassam; Maspero, Jorge; Menzies-Gow, Andrew N.; Newell, Anthony; Sirena, Concetta; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Perez-de-Llano, Luis; Perng (Steve), Diahn Warng; Peters, Matthew; Pfeffer, Paul E.; Porsbjerg, Celeste M.; Popov, Todor A.; Rhee, Chin Kook; Salvi, Sundeep; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Ulrik, Charlotte; Ra, Seung Won; Wang, Eileen; Wechsler, Michael E.; Price, David B. (2023)
      article
      <p>Background: Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective: To examine ...

    • Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma 

      Perez-de-Llano, Luis; Scelo, Ghislaine; Canonica, G. Walter; Chen, Wenjia; Henley, William; Larenas-Linnemann, Désirée; Peters, Matthew J.; Pfeffer, Paul E.; Tran, Trung N.; Ulrik, Charlotte Suppli; Popov, Todor A.; Sadatsafavi, Mohsen; Hew, Mark; Máspero, Jorge; Gibson, Peter G.; Christoff, George C.; Fitzgerald, J. Mark; Torres-Duque, Carlos A.; Porsbjerg, Celeste M.; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Kuna, Piotr; Fonseca, João A.; Al-Lehebi, Riyad; Rhee, Chin Kook; Koh, Mariko Siyue; Cosio, Borja G.; Perng (Steve), Diahn Warng; Mahboub, Bassam; Menzies-Gow, Andrew N.; Jackson, David J.; Busby, John; Heaney, Liam G.; Patel, Pujan H.; Wang, Eileen; Wechsler, Michael E.; Altraja, Alan; Lehtimäki, Lauri; Bourdin, Arnaud; Bjermer, Leif; Bulathsinhala, Lakmini; Carter, Victoria; Murray, Ruth; Beastall, Aaron; Denton, Eve; Price, David B. (12 / 2023)
      article
      Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting ...

    • International severe asthma registry (ISAR): Protocol for a global registry 

      Fitzgerald, J. Mark; Tran, Trung N.; Alacqua, Marianna; Altraja, Alan; Backer, Vibeke; Bjermer, Leif; Bjornsdottir, Unnur; Bourdin, Arnaud; Brusselle, Guy; Bulathsinhala, Lakmini; Busby, John; Canonica, Giorgio W.; Carter, Victoria; Chaudhry, Isha; Cho, You Sook; Christoff, George; Cosio, Borja G.; Costello, Richard W.; Eleangovan, Neva; Gibson, Peter G.; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Hosseini, Naeimeh; Iwanaga, Takashi; Jackson, David J.; Jones, Rupert; Koh, Mariko S.; Le, Thao; Lehtimäki, Lauri; Ludviksdottir, Dora; Maitland-Van Der Zee, Anke H.; Menzies-Gow, Andrew; Murray, Ruth B.; Papadopoulos, Nikolaos G.; Perez-De-Llano, Luis; Peters, Matthew; Pfeffer, Paul E.; Popov, Todor A.; Porsbjerg, Celeste M.; Price, Chris A.; Rhee, Chin K.; Sadatsafavi, Mohsen; Tohda, Yuji; Wang, Eileen; Wechsler, Michael E.; Zangrilli, James; Price, David B. (14.08.2020)
      article
      <p>Background: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical ...

    • Real-world biologics response and super-response in the International Severe Asthma Registry cohort 

      -, -; Denton, Eve; Hew, Mark; Peters, Matthew J.; Upham, John W.; Bulathsinhala, Lakmini; Tran, Trung N.; Martin, Neil; Bergeron, Celine; Al-Ahmad, Mona; Altraja, Alan; Larenas-Linnemann, Désirée; Murray, Ruth; Celis-Preciado, Carlos Andrés; Al-Lehebi, Riyad; Belhassen, Manon; Bhutani, Mohit; Bosnic-Anticevich, Sinthia Z.; Bourdin, Arnaud; Brusselle, Guy G.; Busby, John; Canonica, Giorgio Walter; Heffler, Enrico; Chapman, Kenneth R.; Charriot, Jérémy; Christoff, George C.; Chung, Li Ping; Cosio, Borja G.; Côté, Andréanne; Costello, Richard W.; Cushen, Breda; Fingleton, James; Fonseca, João A.; Gibson, Peter G.; Heaney, Liam G.; Huang, Erick Wan Chun; Iwanaga, Takashi; Jackson, David J.; Koh, Mariko Siyue; Lehtimäki, Lauri; Máspero, Jorge; Mahboub, Bassam; Menzies-Gow, Andrew N.; Mitchell, Patrick D.; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Perez-de-Llano, Luis; Perng, Diahn Warng; Pfeffer, Paul E.; Popov, Todor A.; Porsbjerg, Celeste M.; Rhee, Chin Kook; Roche, Nicolas; Sadatsafavi, Mohsen; Salvi, Sundeep; Schmid, Johannes Martin; Sheu, Chau-Chyun; Sirena, Concetta; Torres-Duque, Carlos A.; Salameh, Laila; Patel, Pujan H.; Ulrik, Charlotte Suppli; Wang, Eileen; Wechsler, Michael E.; Price, David B. (2024)
      article
      Background: Biologic asthma therapies reduce exacerbations and long-term oral corticosteroids (LTOCS) use in randomized controlled trials (RCTs); however, there are limited data on outcomes among patients ineligible for ...