"Tujula, Iisa" - Selaus tekijän mukaan TUNICRIS-julkaisut

Viitteet 1-3 / 3

    • Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease 

      Kapucu, Fikret Emre; Tujula, Iisa; Kulta, Oskari; Sukki, Lassi; Ryynänen, Tomi; Gram, Hjalte; Vuolanto, Valtteri; Vinogradov, Andrey; Kreutzer, Joose; Jensen, Poul Henning; Kallio, Pasi; Narkilahti, Susanna (28.07.2024)
      article
      Previous studies have shown that aggregated alpha-synuclein (α-s) protein, a key pathological marker of Parkinson’s disease (PD), can propagate between cells, thus participating in disease progression. This prion-like ...

    • Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state 

      Hyvärinen, Tanja; Tilvis, Johanna; Giudice, Luca; Tujula, Iisa; Nylund, Marjo; Ohtonen, Sohvi; Scoyni, Flavia; Jäntti, Henna; Virtanen, Lassi; Pihlava, Sara; Kattelus, Roosa; Skottman, Heli; Narkilahti, Susanna; Airas, Laura; Malm, Tarja; Hagman, Sanna (2025)
      article
      Aberrant and sustained activation of microglia is implicated in the progression and severity of multiple sclerosis (MS). However, whether intrinsic alterations in microglial function impact the pathogenesis of this disease ...

    • Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform 

      Tujula, Iisa; Hyvärinen, Tanja; Lotila, Johanna; Rogal, Julia; Voulgaris, Dimitrios; Sukki, Lassi; Tornberg, Kaisa; Korpela, Katri; Jäntti, Henna; Malm, Tarja; Herland, Anna; Kallio, Pasi; Narkilahti, Susanna; Hagman, Sanna (2025)
      article
      Background: Microglia and astrocytes are central mediators of neuroinflammation in several neurodegenerative diseases. Their intricate crosstalk and contributions to pathogenesis remain elusive, highlighting the need for ...