"Taavitsainen, Sinja" - Selaus tekijän mukaan TUNICRIS-julkaisut

Viitteet 1-9 / 9

    • Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine 

      Nurminen, Anssi; Jaatinen, Serafiina; Taavitsainen, Sinja; Högnäs, Gunilla; Lesluyes, Tom; Ansari-Pour, Naser; Tolonen, Teemu; Haase, Kerstin; Koskenalho, Antti; Kankainen, Matti; Jasu, Juho; Rauhala, Hanna; Kesäniemi, Jenni; Nikupaavola, Tiia; Kujala, Paula; Rinta-Kiikka, Irina; Riikonen, Jarno; Kaipia, Antti; Murtola, Teemu; Tammela, Teuvo L.; Visakorpi, Tapio; Nykter, Matti; Wedge, David C.; Van Loo, Peter; Bova, G. Steven (10 / 2023)
      article
      Background: Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical ...

    • Chromatin and epigenetic dysregulation of prostate cancer development, progression, and therapeutic response 

      Kukkonen, Konsta; Taavitsainen, Sinja; Huhtala, Laura; Uusi-Makela, Joonas; Granberg, Kirsi J.; Nykter, Matti; Urbanucci, Alfonso (07 / 2021)
      reviewarticle
      The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, ...

    • Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine 

      Jasu, Juho; Tolonen, Teemu; Antonarakis, Emmanuel S.; Beltran, Himisha; Halabi, Susan; Eisenberger, Mario A.; Carducci, Michael A.; Loriot, Yohann; Van der Eecken, Kim; Lolkema, Martijn; Ryan, Charles J.; Taavitsainen, Sinja; Gillessen, Silke; Högnäs, Gunilla; Talvitie, Timo; Taylor, Robert J.; Koskenalho, Antti; Ost, Piet; Murtola, Teemu J.; Rinta-Kiikka, Irina; Tammela, Teuvo; Auvinen, Anssi; Kujala, Paula; Smith, Thomas J.; Kellokumpu-Lehtinen, Pirkko Liisa; Isaacs, William B.; Nykter, Matti; Kesseli, Juha; Bova, G. Steven (08 / 2021)
      article
      <p>Background: Systematic identification of data essential for outcome prediction in metastatic prostate cancer (mPC) would accelerate development of precision oncology. Objective: To identify novel phenotypes and ...

    • Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression 

      Cao, Shaolong; Wang, Jennifer R.; Ji, Shuangxi; Yang, Peng; Dai, Yaoyi; Guo, Shuai; Montierth, Matthew D.; Shen, John Paul; Zhao, Xiao; Chen, Jingxiao; Lee, Jaewon James; Guerrero, Paola A.; Spetsieris, Nicholas; Engedal, Nikolai; Taavitsainen, Sinja; Yu, Kaixian; Livingstone, Julie; Bhandari, Vinayak; Hubert, Shawna M.; Daw, Najat C.; Futreal, P. Andrew; Efstathiou, Eleni; Lim, Bora; Viale, Andrea; Zhang, Jianjun; Nykter, Matti; Czerniak, Bogdan A.; Brown, Powel H.; Swanton, Charles; Msaouel, Pavlos; Maitra, Anirban; Kopetz, Scott; Campbell, Peter; Speed, Terence P.; Boutros, Paul C.; Zhu, Hongtu; Urbanucci, Alfonso; Demeulemeester, Jonas; Van Loo, Peter; Wang, Wenyi (2022)
      article
      Single-cell RNA sequencing studies have suggested that total mRNA content correlates with tumor phenotypes. Technical and analytical challenges, however, have so far impeded at-scale pan-cancer examination of total mRNA ...

    • Fanconi anemia pathway regulation by FANCI in prostate cancer 

      Kaljunen, Heidi; Taavitsainen, Sinja; Kaarijärvi, Roosa; Takala, Eerika; Paakinaho, Ville; Nykter, Matti; Bova, G Steven; Ketola, Kirsi (2023)
      article
      Prostate cancer is one of the leading causes of death among men worldwide, and thus, research on the genetic factors enabling the formation of treatment-resistant cancer cells is crucial for improving patient outcomes. ...

    • Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer 

      Vandekerkhove, Gillian; Lavoie, Jean Michel; Annala, Matti; Murtha, Andrew J.; Sundahl, Nora; Walz, Simon; Sano, Takeshi; Taavitsainen, Sinja; Ritch, Elie; Fazli, Ladan; Hurtado-Coll, Antonio; Wang, Gang; Nykter, Matti; Black, Peter C.; Todenhöfer, Tilman; Ost, Piet; Gibb, Ewan A.; Chi, Kim N.; Eigl, Bernhard J.; Wyatt, Alexander W. (2021)
      article
      Molecular stratification can improve the management of advanced cancers, but requires relevant tumor samples. Metastatic urothelial carcinoma (mUC) is poised to benefit given a recent expansion of treatment options and its ...

    • Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer 

      Fonseca, Nicolette M.; Maurice-Dror, Corinne; Herberts, Cameron; Tu, Wilson; Fan, William; Murtha, Andrew J.; Kollmannsberger, Catarina; Kwan, Edmond M.; Parekh, Karan; Schönlau, Elena; Bernales, Cecily Q.; Donnellan, Gráinne; Ng, Sarah W.S.; Sumiyoshi, Takayuki; Vergidis, Joanna; Noonan, Krista; Finch, Daygen L.; Zulfiqar, Muhammad; Miller, Stacy; Parimi, Sunil; Lavoie, Jean Michel; Hardy, Edward; Soleimani, Maryam; Nappi, Lucia; Eigl, Bernhard J.; Kollmannsberger, Christian; Taavitsainen, Sinja; Nykter, Matti; Tolmeijer, Sofie H.; Boerrigter, Emmy; Mehra, Niven; van Erp, Nielka P.; De Laere, Bram; Lindberg, Johan; Grönberg, Henrik; Khalaf, Daniel J.; Annala, Matti; Chi, Kim N.; Wyatt, Alexander W. (2024)
      article
      No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by commercial and laboratory tests but its utility ...

    • Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer 

      Kiviaho, Antti; Eerola, Sini K.; Kallio, Heini M.L.; Andersen, Maria K.; Hoikka, Miina; Tiihonen, Aliisa M.; Salonen, Iida; Spotbeen, Xander; Giesen, Alexander; Parker, Charles T.A.; Taavitsainen, Sinja; Hantula, Olli; Marttinen, Mikael; Hermelo, Ismaïl; Ismail, Mazlina; Midtbust, Elise; Wess, Maximilian; Devlies, Wout; Sharma, Abhibhav; Krossa, Sebastian; Häkkinen, Tomi; Afyounian, Ebrahim; Vandereyken, Katy; Kint, Sam; Kesseli, Juha; Tolonen, Teemu; Tammela, Teuvo L.J.; Viset, Trond; Størkersen, Øystein; Giskeødegård, Guro F.; Rye, Morten B.; Murtola, Teemu; Erickson, Andrew; Latonen, Leena; Bova, G. Steven; Mills, Ian G.; Joniau, Steven; Swinnen, Johannes V.; Voet, Thierry; Mirtti, Tuomas; Attard, Gerhardt; Claessens, Frank; Visakorpi, Tapio; Rautajoki, Kirsi J.; Tessem, May Britt; Urbanucci, Alfonso; Nykter, Matti (11 / 2024)
      article
      Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated the mechanisms through which cancer cells escape treatment, but their relation ...

    • Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity 

      Ketola, Kirsi; Kaljunen, Heidi; Taavitsainen, Sinja; Kaarijärvi, Roosa; Järvelä, Emmi; Rodríguez-Martín, Bernardo; Haase, Kerstin; Woodcock, Dan J.; Tubio, Jose; Wedge, David C.; Nykter, Matti; Steven Bova, G. (2021)
      article
      Treatment-eradicated cancer subclones have been reported in leukemia and have recently been detected in solid tumors. Here we introduce Differential Subclone Eradication and Resistance (DSER) analysis, a method developed ...