"Smirnov, Aleksei" - Selaus tekijän mukaan TUNICRIS-julkaisut

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    • A<sub>2A</sub> receptor antagonist 4-(2-((6-Amino-9-ethyl-8-(furan-2-yl)-9H-purin-2-yl)amino)ethyl)phenol, a promising adenosine derivative for glioblastoma treatment 

      Murugesan, Akshaya; Smirnov, Aleksei; Alonso, Anxo Vila; Buccioni, Michela; Cui, Chang; Dal Ben, Diego; Francucci, Beatrice; Lambertucci, Catia; Marucci, Gabriella; Volpini, Rosaria; Konda Mani, Saravanan; Devanesan, Sandhanasamy; AlSalhi, Mohamad S.; Yli-Harja, Olli; Spinaci, Andrea; Kandhavelu, Meenakshisundaram (01.04.2025)
      article
      Adenosine, a pervasive signaling molecule mediated by its interaction with G-protein-coupled receptor subtypes, especially the A2A adenosine receptor (A2AAR), plays a crucial role in cancer treatment. Recently, A2AAR ...

    • Comparative analysis of the antiglioblastoma activity of adenosine A<sub>2A</sub> receptor and CK1δ blockers 

      Murugesan, Akshaya; Alonso, Anxo Vila; Konda Mani, Saravanan; Sarkar, Puja; Smirnov, Aleksei; Francucci, Beatrice; Marucci, Gabriella; Buccioni, Michela; Abass, Kasim S.; Sureka, Chandrabose; Yli-Harja, Olli; Kandhavelu, Meenakshisundaram (05.09.2025)
      article
      Glioblastoma multiforme (GBM), a multifactorial deadliest cancer with constrained clinical efficacy due to heterogeneity, drug resistance, side effects of the chemotherapeutic drug, necessitating the development of novel ...

    • Preclinical validation of tetrahydroquinoline derivatives as EGFR inhibitor inducing glioblastoma cell death 

      Murugesan, Akshaya; Mani, Saravanan Konda; Smirnov, Aleksei; Koochakkhani, Shabnaz; Nambi Narayanan, Sabarish; Branco, Daniela S.N.; Devanesan, Sandhanasamy; Wadaan, Mohammad Ahmad; Candeias, Nuno R.; Kandhavelu, Meenakshisundaram (01.06.2026)
      article
      Glioblastoma multiforme, a malignant brain tumor has a dismal prognosis and lacks effective treatment. Epidermal growth factor receptor (EGFR) is an attractive drug target for GBM treatment, yet no therapeutic effect has ...