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PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation

Schulz, Carl; Lemoine, Marc D.; Mearini, Giulia; Koivumäki, Jussi; Sani, Jascha; Schwedhelm, Edzard; Kirchhof, Paulus; Ghalawinji, Amer; Stoll, Monika; Hansen, Arne; Eschenhagen, Thomas; Christ, Torsten (03 / 2023)
article

Background: Electrical remodeling in human persistent atrial fibrillation is believed to result from rapid electrical activation of the atria, but underlying genetic causes may contribute. Indeed, common gene variants in ...
Regulation of APD and Force by the Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue

Ismaili, Djemail; Gurr, Katrin; Horváth, András; Yuan, Lei; Lemoine, Marc D.; Schulz, Carl; Sani, Jascha; Petersen, Johannes; Reichenspurner, Hermann; Kirchhof, Paulus; Jespersen, Thomas; Eschenhagen, Thomas; Hansen, Arne; Koivumäki, Jussi T.; Christ, Torsten (05.08.2022)
article

The physiological importance of NCX in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is not well characterized but may depend on the relative strength of the current, compared to adult cardiomyocytes, ...