TUNICRIS-julkaisut - Trepo

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Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia

Malyukova, Alena; Lahnalampi, Mari; Falqués-Costa, Ton; Pölönen, Petri; Sipola, Mikko; Mehtonen, Juha; Teppo, Susanna; Akopyan, Karen; Viiliainen, Johanna; Lohi, Olli; Hagström-Andersson, Anna K.; Heinäniemi, Merja; Sangfelt, Olle (12 / 2024)
article

Background: Targeted therapies exploiting vulnerabilities of cancer cells hold promise for improving patient outcome and reducing side-effects of chemotherapy. However, efficacy of precision therapies is limited in part ...
Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

Mehtonen, Juha; Teppo, Susanna; Lahnalampi, Mari; Kokko, Aleksi; Kaukonen, Riina; Oksa, Laura; Bouvy-Liivrand, Maria; Malyukova, Alena; Mäkinen, Artturi; Laukkanen, Saara; Mäkinen, Petri I.; Rounioja, Samuli; Ruusuvuori, Pekka; Sangfelt, Olle; Lund, Riikka; Lönnberg, Tapio; Lohi, Olli; Heinäniemi, Merja (2020)
article

Background: Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic ...