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DNA methylation levels in mononuclear leukocytes from the mother and her child are associated with IgE sensitization to allergens in early life

Acevedo, Nathalie; Scala, Giovanni; Merid, Simon Kebede; Frumento, Paolo; Bruhn, Sören; Andersson, Anna; Ogris, Christoph; Bottai, Matteo; Pershagen, Göran; Koppelman, Gerard H.; Melén, Erik; Sonnhammer, Erik; Alm, Johan; Söderhäll, Cilla; Kere, Juha; Greco, Dario; Scheynius, Annika (01 / 2021)
article

DNA methylation changes may predispose becoming IgE-sensitized to allergens. We analyzed whether DNA methylation in peripheral blood mononuclear cells (PBMC) is associated with IgE sensitization at 5 years of age (5Y). DNA ...
Epigenetic alterations in skin homing CD4<sup>+</sup>CLA<sup>+</sup> T cells of atopic dermatitis patients

Acevedo, Nathalie; Benfeitas, Rui; Katayama, Shintaro; Bruhn, Sören; Andersson, Anna; Wikberg, Gustav; Lundeberg, Lena; Lindvall, Jessica M.; Greco, Dario; Kere, Juha; Söderhäll, Cilla; Scheynius, Annika (2020)
article

T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate ...