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    • Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia 

      Auvinen, Juha; Tapio, Joona; Karhunen, Ville; Kettunen, Johannes; Serpi, Raisa; Dimova, Elitsa Y.; Gill, Dipender; Soininen, Pasi; Tammelin, Tuija; Mykkänen, Juha; Puukka, Katri; Kähönen, Mika; Raitoharju, Emma; Lehtimäki, Terho; Ala-Korpela, Mika; Raitakari, Olli T.; Keinänen-Kiukaanniemi, Sirkka; Järvelin, Marjo Riitta; Koivunen, Peppi (2021)
      article
      Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower ...