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Disruption of androgen receptor-cofactor interactions by the RNA-binding protein FUS/TLS alters androgen signalling in prostate cancer

Brooke, G. N.; Leach, D. A.; Culley, R. L.; Azadova, A.; Latonen, L.; Rees, E.; Alkheilewi, M. A.; Pine, A. C.; Fioretti, F. M.; Reader, C. S.; Powell, S. M.; Reebye, V.; Waxman, J.; Visakorpi, T.; Bevan, C. L. (2026)
article

Prostate cancer is dependent upon the androgen receptor (AR), the activity of which is modified by cofactors that either enhance or repress its activity, often in a context-dependent manner. FUS/TLS is a multifunctional ...