"Nymark, Soile" - Selaus tekijän mukaan TUNICRIS-julkaisut
Viitteet 1-20 / 22
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Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells
(2020)
articleSurface topography is a key parameter in regulating the morphology and behavior of single cells. At multicellular level, coordinated cell displacements drive many biological events such as embryonic morphogenesis. However, ... -
Biomimetic hydrogel platform reveals active force transduction from retinal pigment epithelium to photoreceptors
(2025)
articleIn the eye, the retinal pigment epithelium (RPE) maintains the functionality and welfare of retinal photoreceptors and forms a tight, interlocked structure with photoreceptor outer segments (POSs). The RPE-retina interaction ... -
Cell maturation influences the ability of hESC-RPE to tolerate cellular stress
(01 / 2022)
article<p>Background: Transplantation of human pluripotent stem cell-derived retinal pigment epithelium (RPE) is an urgently needed treatment for the cure of degenerative diseases of the retina. The transplanted cells must ... -
Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex
(06 / 2025)
articlePURPOSE. Our understanding of ocular clocks has been profoundly advanced by the development of real-time recording of bioluminescence of PER2-luciferase (PER2::LUC) knock-in mouse explants. However, the effect of sex, mouse ... -
Crosstalk of protein clearance, inflammasome, and Ca<sup>2+</sup> channels in retinal pigment epithelium derived from age-related macular degeneration patients
(06 / 2023)
article<p>Degeneration and/or dysfunction of retinal pigment epithelium (RPE) is generally detected as the formation of intracellular and extracellular protein aggregates, called lipofuscin and drusen, respectively, in ... -
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE
(2021)
articleHuman pluripotent stem cell-derived retinal pigment epithelium (RPE) transplantation is currently under evaluation as treatment for macular degeneration. For therapeutic applications, cryostorage during cell production is ... -
The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales
(07 / 2023)
articlePurpose: The importance of mechanical forces and microenvironment in guiding cellular behavior has been widely accepted. Together with the extracellular matrix (ECM), epithelial cells form a highly connected mechanical ... -
Exploring the impact of human pluripotent stem cell heterogeneity on corneal limbal stem cell differentiation outcomes
(2026)
articleDifferentiation of limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) shows promise for treating bilateral limbal stem cell deficiency. However, variation in hPSCs can compromise cell production protocols ... -
Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium
(2018)
articleRetinal pigment epithelium (RPE) performs important functions for the maintenance of photoreceptors and vision. Malfunctions within the RPE are implicated in several retinal diseases for which transplantations of stem ... -
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium
(11.03.2022)
articleGap junctions are intercellular channels that permit the transfer of ions and small molecules between adjacent cells. These cellular junctions are particularly dense in the retinal pigment epithelium (RPE), and their ... -
Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium
(2022)
article<p>Human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) is extensively used in RPE research, disease modeling, and transplantation therapies. For successful outcomes, a thorough evaluation of ... -
Iterative Immunostaining and NEDD Denoising for Improved Signal-To-Noise Ratio in ExM-LSCM
(20.09.2024)
articleExpansion microscopy (ExM) has significantly reformed the field of super-resolution imaging, emerging as a powerful tool for visualizing complex cellular structures with nanoscale precision. Despite its capabilities, the ... -
Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina
(08 / 2023)
articleInvestigation of nuclear lamina architecture relies on super-resolved microscopy. However, epitope accessibility, labeling density, and detection precision of individual molecules pose challenges within the molecularly ... -
Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular Ca2+ Increase via Mechanosensitive Cation Channels
(09.11.2023)
articleEpithelial cells are in continuous dynamic biochemical and physical interaction with their extracellular environment. Ultimately, this interplay guides fundamental physiological processes. In these interactions, cells ... -
Light-Responsive Bilayer Cell Culture Platform for Reversible Cell Guidance
(16.12.2021)
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Phagocytosed Photoreceptor Outer Segment Particles Within the Retinal Pigment Epithelium Show Diurnal Rhythmicity and Variation Between Cone Subtypes in Larval Zebrafish
(31.07.2025)
articlePhagocytosis of retinal rod and cone outer segment (OS) tips by the retinal pigment epithelium (RPE) occurs daily to prevent the accumulation of harmful compounds in the photoreceptors. Rhythmic bursts seen as increased ... -
Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology
(03.06.2022)
articleIt is well established that mechanical cues, e.g., tensile- compressive- or shear forces, are important co-regulators of cell and tissue physiology. To understand the mechanistic effects these cues have on cells, technologies ... -
The retinal pigment epithelium displays electrical excitability and lateral signal spreading
(2023)
article<p>Background: The non-neuronal retinal pigment epithelium (RPE) functions in intimate association with retinal photoreceptors, performing a multitude of tasks critical for maintaining retinal homeostasis and ... -
Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods
(07 / 2016)
article<p>Photoactivation of vertebrate rhodopsin converts it to the physiologically active Meta II (R-star) state, which triggers the rod light response. Meta II is rapidly inactivated by the phosphorylation of C-terminal ... -
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium
(2019)
articleBackground: Voltage-gated sodium (Nav) channels have traditionally been considered a trademark of excitable cells. However, recent studies have shown the presence of Nav channels in several non-excitable cells, such as ...
