"Mykuliak, Vasyl V." - Selaus tekijän mukaan TUNICRIS-julkaisut
Viitteet 1-7 / 7
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Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity
(21.06.2024)
articleIntegrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood. ... -
Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis
(2021)
article<p>Abstract: Trichomonas vaginalis is a unicellular parasite and responsible for one of the most common sexually transmittable infections worldwide, trichomoniasis. Carbonic anhydrases (CAs) are enzymes found in all ... -
Cancer associated talin point mutations disorganise cell adhesion and migration
(2021)
article<p>Talin-1 is a key component of the multiprotein adhesion complexes which mediate cell migration, adhesion and integrin signalling and has been linked to cancer in several studies. We analysed talin-1 mutations ... -
Microfluidics-Based Force Spectroscopy Enables High-Throughput Force Experiments with Sub-Nanometer Resolution and Sub-Piconewton Sensitivity
(2023)
article<p>Several techniques have been established to quantify the mechanicals of single molecules. However, most of them show only limited capabilities of parallelizing the measurement by performing many individual ... -
Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force
(08 / 2024)
articleVinculin binds to specific sites of mechanically unfolded talin rod domains to reinforce the coupling of the cell's exterior to its force generation machinery. Force-dependent vinculin- talin complexation and dissociation ... -
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function
(09 / 2025)
articleTalin-1 is a central integrin adapter protein connecting cytoplasmic domains of integrins to the cytoskeleton. These talin-1-mediated mechanical linkages are crucial for cellular functions such as cell movement and connections ...
