TUNICRIS-julkaisut - Trepo

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Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms

Azizi, Latifeh; Varela, Lorena; Turkki, Paula; Mykuliak, Vasyl V; Korpela, Sanna; Ihalainen, Teemu O; Church, Joseph; Hytönen, Vesa P; Goult, Benjamin T (15.12.2022)
article

Adhesion of cells to the extracellular matrix (ECM) must be exquisitely coordinated to enable development and tissue homeostasis. Cell-ECM interactions are regulated by multiple signalling pathways that coordinate the ...
Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease

Azizi, Latifeh; Otani, Yasumi; Mykuliak, Vasyl V; Goult, Benjamin T; Hytönen, Vesa P; Turkki, Paula (01.11.2024)
article

Variants of talin-1 (TLN1) have recently been linked with spontaneous coronary artery dissection (SCAD) a condition where a tear can form in the wall of a heart artery necessitating immediate medical care. One talin-1 ...