"Mykkänen, Juha" - Selaus tekijän mukaan TUNICRIS-julkaisut
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Association of Serum Trimethylamine-N-Oxide Concentration from Childhood to Early Adulthood with Age and Sex
Almer, Gunter; Enko, Dietmar; Kartiosuo, Noora; Niinikoski, Harri; Lehtimäki, Terho; Munukka, Eveliina; Viikari, Jorma; Rönnemaa, Tapani; Rovio, Suvi P.; Mykkänen, Juha; Lagström, Hanna; Jula, Antti; Herrmann, Markus; Raitakari, Olli T.; Meinitzer, Andreas; Pahkala, Katja (09 / 2024)
articleBackground: Primary prevention is the cornerstone of cardiometabolic health. In the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP), dietary counseling intervention was given to ... -
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes
Davis-Richardson, Austin G; Davis-Rishardson, A; Ardissone, Alexandria N; Dias, Raquel; Simell, Ville; Leonard, Michael T; Kemppainen, Kaisa M; Drew, Jennifer C; Schatz, Desmond; Atkinson, Mark A; Kolaczkowski, Bryan; Ilonen, Jorma; Knip, Mikael; Toppari, Jorma; Nurminen, Noora; Hyöty, Heikki; Veijola, Riitta; Simell, Tuula; Mykkänen, Juha; Simell, Olli; Triplett, Eric W (2014)
articleThe incidence of the autoimmune disease, type 1 diabetes (T1D), has increased dramatically over the last half century in many developed countries and is particularly high in Finland and other Nordic countries. Along with ... -
Childhood exposure to parental smoking and life-course overweight and central obesity
Jaakkola, Johanna M; Rovio, Suvi P; Pahkala, Katja; Viikari, Jorma; Rönnemaa, Tapani; Jula, Antti; Niinikoski, Harri; Mykkänen, Juha; Juonala, Markus; Hutri-Kähönen, Nina; Kähönen, Mika; Lehtimäki, Terho; Raitakari, Olli T (2020)
articleOBJECTIVE: To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood. METHODS: This study leverages the data from two longitudinal population ... -
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
Takaoka, Minoru; Zhao, Xiaohui; Lim, Hwee Ying; Magnussen, Costan G.; Ang, Owen; Suffee, Nadine; Schrank, Patricia R.; Ong, Wei Siong; Tsiantoulas, Dimitrios; Sommer, Felix; Mohanta, Sarajo K.; Harrison, James; Meng, Yaxing; Laurans, Ludivine; Wu, Feitong; Lu, Yuning; Masters, Leanne; Newland, Stephen A.; Denti, Laura; Hong, Mingyang; Chajadine, Mouna; Juonala, Markus; Koskinen, Juhani S.; Kähönen, Mika; Pahkala, Katja; Rovio, Suvi P.; Mykkänen, Juha; Thomson, Russell; Kaisho, Tsuneyasu; Habenicht, Andreas J.R.; Clement, Marc; Tedgui, Alain; Ait-Oufella, Hafid; Zhao, Tian X.; Nus, Meritxell; Ruhrberg, Christiana; Taleb, Soraya; Williams, Jesse W.; Raitakari, Olli T.; Angeli, Véronique; Mallat, Ziad (2024)
articleHyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, ... -
Evaluating the direct effects of childhood adiposity on adult systemic metabolism : A multivariable Mendelian randomization analysis
Richardson, Tom G.; Mykkänen, Juha; Pahkala, Katja; Ala-Korpela, Mika; Bell, Joshua A.; Taylor, Kurt; Viikari, Jorma; Lehtimäki, Terho; Raitakari, Olli; Smith, George Davey (2021)
articleBackground: Individuals who are obese in childhood have an elevated risk of disease in adulthood. However, whether childhood adiposity directly impacts intermediate markers of this risk, independently of adult adiposity, ... -
Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data
Drouard, Gabin; Mykkänen, Juha; Heiskanen, Jarkko; Pohjonen, Joona; Ruohonen, Saku; Pahkala, Katja; Lehtimäki, Terho; Wang, Xiaoling; Ollikainen, Miina; Ripatti, Samuli; Pirinen, Matti; Raitakari, Olli; Kaprio, Jaakko (2024)
articleBackground: Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class ... -
Glycoprotein Acetyls : A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young
Chiesa, Scott T.; Charakida, Marietta; Georgiopoulos, Georgios; Roberts, Justin D.; Stafford, Simon J.; Park, Chloe; Mykkänen, Juha; Kähönen, Mika; Lehtimäki, Terho; Ala-Korpela, Mika; Raitakari, Olli; Pietiäinen, Milla; Pussinen, Pirkko; Muthurangu, Vivek; Hughes, Alun D.; Sattar, Naveed; Timpson, Nicholas J.; Deanfield, John E. (02 / 2022)
articleBackground Low-grade inflammation in the young may contribute to the early development of cardiovascular disease. We assessed whether circulating levels of glycoprotein acetyls (GlycA) were better able to predict the ... -
Hyödynnettävän tiedon edellytyksistä tiedon hyötykäyttöön – takakaarteesta loppusuoralle?
Jylhä, Virpi; Värri, Alpo; Mykkänen, Juha (27.05.2024)
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Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study
Raitakari, Olli; Kivelä, Annukka; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Ahola-Olli, Ari; Loo, Britt Marie; Lyytikäinen, Leo Pekka; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Rönnemaa, Tapani; Lamina, Claudia; Kronenberg, Florian; Viikari, Jorma (09 / 2022)
articleBackground and aims: Lipoprotein (a) (Lp(a)) is a causal risk factor for cardiovascular diseases and its levels are under strict genetic control. Therefore, it is hypothesized that the concentration of Lp(a) remains stable ... -
Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values
Drouard, Gabin; Ollikainen, Miina; Mykkänen, Juha; Raitakari, Olli; Lehtimäki, Terho; Kähönen, Mika; Mishra, Pashupati P.; Wang, Xiaoling; Kaprio, Jaakko (2022)
articleAbnormal blood pressure is strongly associated with risk of high-prevalence diseases, making the study of blood pressure a major public health challenge. Although biological mechanisms underlying hypertension at the single ... -
Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples
Laajala, Essi; Halla-aho, Viivi; Grönroos, Toni; Kalim, Ubaid Ullah; Vähä-Mäkilä, Mari; Nurmio, Mirja; Kallionpää, Henna; Lietzén, Niina; Mykkänen, Juha; Rasool, Omid; Toppari, Jorma; Orešič, Matej; Knip, Mikael; Lund, Riikka; Lahesmaa, Riitta; Lähdesmäki, Harri (03 / 2022)
articleDNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, ... -
Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature
Repo, Oskari; Juonala, Markus; Niinikoski, Harri; Rovio, Suvi; Mykkänen, Juha; Lagström, Hanna; Cheung, Carol Y.; Yang, Dawei; Vaahtoranta-Lehtonen, Hanna; Jula, Antti; Nevalainen, Jaakko; Rönnemaa, Tapani; Viikari, Jorma; Raitakari, Olli; Tapp, Robyn; Pahkala, Katja (01.09.2024)
articleBackground and Aims Retinal microvasculature characteristics predict cardiovascular morbidity and mortality. This study investigated associations of lifelong cardiovascular risk factors and effects of dietary intervention ... -
Sotetite-tutkimuspäivät tutkijan ja tutkimusryhmän näkökulmasta
Jylhä, Virpi; Mykkänen, Juha; Värri, Alpo (09.05.2022)
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Subclinical atherosclerosis in young adults predicting cardiovascular disease : The Cardiovascular Risk in Young Finns Study
Raitakari, Olli T.; Magnussen, Costan G.; Juonala, Markus; Kartiosuo, Noora; Pahkala, Katja; Rovio, Suvi; Koskinen, Juhani S.; Mykkänen, Juha; Laitinen, Tomi P.; Kähönen, Mika; Nuotio, Joel; Viikari, Jorma S.A. (2024)
articleBackground and aims: Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are ... -
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia
Auvinen, Juha; Tapio, Joona; Karhunen, Ville; Kettunen, Johannes; Serpi, Raisa; Dimova, Elitsa Y.; Gill, Dipender; Soininen, Pasi; Tammelin, Tuija; Mykkänen, Juha; Puukka, Katri; Kähönen, Mika; Raitoharju, Emma; Lehtimäki, Terho; Ala-Korpela, Mika; Raitakari, Olli T.; Keinänen-Kiukaanniemi, Sirkka; Järvelin, Marjo Riitta; Koivunen, Peppi (2021)
articleActivation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower ... -
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
Early Growth Genetics Consortium; Bradfield, Jonathan P.; Kember, Rachel L.; Ulrich, Anna; Balkiyarova, Zhanna; Alyass, Akram; Aris, Izzuddin M.; Bell, Joshua A.; Broadaway, K. Alaine; Chen, Zhanghua; Chai, Jin Fang; Davies, Neil M.; Fernandez-Orth, Dietmar; Bustamante, Mariona; Fore, Ruby; Ganguli, Amitavo; Heiskala, Anni; Hottenga, Jouke Jan; Íñiguez, Carmen; Kobes, Sayuko; Leinonen, Jaakko; Lowry, Estelle; Lyytikainen, Leo Pekka; Mahajan, Anubha; Pitkänen, Niina; Schnurr, Theresia M.; Have, Christian Theil; Strachan, David P.; Thiering, Elisabeth; Vogelezang, Suzanne; Wade, Kaitlin H.; Wang, Carol A.; Wong, Andrew; Holm, Louise Aas; Chesi, Alessandra; Choong, Catherine; Cruz, Miguel; Elliott, Paul; Franks, Steve; Frithioff-Bøjsøe, Christine; Gauderman, W. James; Glessner, Joseph T.; Gilsanz, Vicente; Griesman, Kendra; Hanson, Robert L.; Kähönen, Mika; Mononen, Nina; Eriksson, Johan G.; Lehtimäki, Terho; Mykkänen, Juha; Shepherd, John A. (16.01.2024)
articleBACKGROUND: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Imposition ... -
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
Laajala, Essi; Kalim, Ubaid Ullah; Grönroos, Toni; Rasool, Omid; Halla-aho, Viivi; Konki, Mikko; Kattelus, Roosa; Mykkänen, Juha; Nurmio, Mirja; Vähä-Mäkilä, Mari; Kallionpää, Henna; Lietzén, Niina; Ghimire, Bishwa R.; Laiho, Asta; Hyöty, Heikki; Elo, Laura L.; Ilonen, Jorma; Knip, Mikael; Lund, Riikka J.; Orešič, Matej; Veijola, Riitta; Lähdesmäki, Harri; Toppari, Jorma; Lahesmaa, Riitta (2022)
articleAims/hypothesis: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated ... -
Yhteinen sote-tieto? - Tiedon toisiokäyttö ja digitalisaation vaikutukset
Jylhä, Virpi; Mykkänen, Juha; Värri, Alpo; Kinnunen, Ulla-Mari; Peltonen, Laura-Maria (10.11.2021)
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