"Mykkänen, Juha" - Selaus tekijän mukaan TUNICRIS-julkaisut

Viitteet 1-20 / 23

    • Association of epicardial adipose tissue thickness and cardiac structure and function in early midlife: the cardiovascular risk in Young Finns Study 

      Gustafsson, Behnoush; Rovio, Suvi P.; Ruohonen, Saku; Mykkänen, Juha; Lehtimäki, Terho; Jokinen, Eero; Tossavainen, Päivi; Laitinen, Tomi P.; Kähönen, Mika; Viikari, Jorma S.; Pahkala, Katja; Raitakari, Olli T. (02.07.2025)
      article

    • Association of Serum Trimethylamine-N-Oxide Concentration from Childhood to Early Adulthood with Age and Sex 

      Almer, Gunter; Enko, Dietmar; Kartiosuo, Noora; Niinikoski, Harri; Lehtimäki, Terho; Munukka, Eveliina; Viikari, Jorma; Rönnemaa, Tapani; Rovio, Suvi P.; Mykkänen, Juha; Lagström, Hanna; Jula, Antti; Herrmann, Markus; Raitakari, Olli T.; Meinitzer, Andreas; Pahkala, Katja (09 / 2024)
      article
      Background: Primary prevention is the cornerstone of cardiometabolic health. In the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP), dietary counseling intervention was given to ...

    • Associations of Cumulative Adulthood, Childhood and Lifelong Insulin With Adulthood Retinal Microvasculature 

      Repo, Oskari; Juonala, Markus; Rovio, Suvi P.; Mykkänen, Juha; Nevalainen, Jaakko; Kähönen, Mika; Lehtimäki, Terho; Laitinen, Tomi P.; Viikari, Jorma; Raitakari, Olli; Tapp, Robyn; Pahkala, Katja (2024)
      article

    • Childhood exposure to parental smoking and life-course overweight and central obesity 

      Jaakkola, Johanna M; Rovio, Suvi P; Pahkala, Katja; Viikari, Jorma; Rönnemaa, Tapani; Jula, Antti; Niinikoski, Harri; Mykkänen, Juha; Juonala, Markus; Hutri-Kähönen, Nina; Kähönen, Mika; Lehtimäki, Terho; Raitakari, Olli T (2020)
      article
      <p>OBJECTIVE: To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood.</p><p>METHODS: This study leverages the data from two ...

    • Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis 

      Takaoka, Minoru; Zhao, Xiaohui; Lim, Hwee Ying; Magnussen, Costan G.; Ang, Owen; Suffee, Nadine; Schrank, Patricia R.; Ong, Wei Siong; Tsiantoulas, Dimitrios; Sommer, Felix; Mohanta, Sarajo K.; Harrison, James; Meng, Yaxing; Laurans, Ludivine; Wu, Feitong; Lu, Yuning; Masters, Leanne; Newland, Stephen A.; Denti, Laura; Hong, Mingyang; Chajadine, Mouna; Juonala, Markus; Koskinen, Juhani S.; Kähönen, Mika; Pahkala, Katja; Rovio, Suvi P.; Mykkänen, Juha; Thomson, Russell; Kaisho, Tsuneyasu; Habenicht, Andreas J.R.; Clement, Marc; Tedgui, Alain; Ait-Oufella, Hafid; Zhao, Tian X.; Nus, Meritxell; Ruhrberg, Christiana; Taleb, Soraya; Williams, Jesse W.; Raitakari, Olli T.; Angeli, Véronique; Mallat, Ziad (2024)
      article
      Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, ...

    • The effect of polychlorinated biphenyls on type 2 diabetes risk is mediated via DNA methylation 

      Kartiosuo, Noora; Auranen, Kari; Mansell, Toby; Novakovic, Boris; Nevalainen, Jaakko; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Viikari, Jorma; Juonala, Markus; Rantakokko, Panu; Kiviranta, Hannu; Kaikkonen, Jari; Lehtimäki, Terho; Raitoharju, Emma; Mishra, Pashupati P; Kähönen, Mika; Ponsonby, Anne-Louise; Tanner, Sam; Burgner, David; Raitakari, Olli; Saffery, Richard (2025)
      article
      Polychlorinated biphenyls (PCBs) have been identified as diabetogens and potential epigenetic regulators. Epigenetic variation is implicated in the pathogenesis of type 2 diabetes (T2D) and is therefore a potential mechanism ...

    • Evaluating the direct effects of childhood adiposity on adult systemic metabolism: A multivariable Mendelian randomization analysis 

      Richardson, Tom G.; Mykkänen, Juha; Pahkala, Katja; Ala-Korpela, Mika; Bell, Joshua A.; Taylor, Kurt; Viikari, Jorma; Lehtimäki, Terho; Raitakari, Olli; Smith, George Davey (2021)
      article
      Background: Individuals who are obese in childhood have an elevated risk of disease in adulthood. However, whether childhood adiposity directly impacts intermediate markers of this risk, independently of adult adiposity, ...

    • Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data 

      Drouard, Gabin; Mykkänen, Juha; Heiskanen, Jarkko; Pohjonen, Joona; Ruohonen, Saku; Pahkala, Katja; Lehtimäki, Terho; Wang, Xiaoling; Ollikainen, Miina; Ripatti, Samuli; Pirinen, Matti; Raitakari, Olli; Kaprio, Jaakko (2024)
      article
      Background: Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class ...

    • Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study 

      Heiskanen, Marja A.; Mykkänen, Juha; Pahkala, Katja; Juonala, Markus; Kähönen, Mika; Lehtimäki, Terho; Laitinen, Tomi P.; Jokinen, Eero; Tossavainen, Päivi; Linko-Parvinen, Anna; Pallari, Hanna Mari; Blennow, Kaj; Zetterberg, Henrik; Viikari, Jorma; Raitakari, Olli; Rovio, Suvi P. (06 / 2025)
      article
      Background: Blood-based biomarkers (BBM) of neurodegenerative diseases are emerging as cost-effective tools in the differential diagnostics of Alzheimer's disease and other dementias. Scarce data exist about factors ...

    • Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young 

      Chiesa, Scott T.; Charakida, Marietta; Georgiopoulos, Georgios; Roberts, Justin D.; Stafford, Simon J.; Park, Chloe; Mykkänen, Juha; Kähönen, Mika; Lehtimäki, Terho; Ala-Korpela, Mika; Raitakari, Olli; Pietiäinen, Milla; Pussinen, Pirkko; Muthurangu, Vivek; Hughes, Alun D.; Sattar, Naveed; Timpson, Nicholas J.; Deanfield, John E. (02 / 2022)
      article
      Background Low-grade inflammation in the young may contribute to the early development of cardiovascular disease. We assessed whether circulating levels of glycoprotein acetyls (GlycA) were better able to predict the ...

    • Hyödynnettävän tiedon edellytyksistä tiedon hyötykäyttöön – takakaarteesta loppusuoralle? 

      Jylhä, Virpi; Värri, Alpo; Mykkänen, Juha (27.05.2024)
      editorial

    • Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study 

      Raitakari, Olli; Kivelä, Annukka; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Ahola-Olli, Ari; Loo, Britt Marie; Lyytikäinen, Leo Pekka; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Rönnemaa, Tapani; Lamina, Claudia; Kronenberg, Florian; Viikari, Jorma (09 / 2022)
      article
      Background and aims: Lipoprotein (a) (Lp(a)) is a causal risk factor for cardiovascular diseases and its levels are under strict genetic control. Therefore, it is hypothesized that the concentration of Lp(a) remains stable ...

    • Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values 

      Drouard, Gabin; Ollikainen, Miina; Mykkänen, Juha; Raitakari, Olli; Lehtimäki, Terho; Kähönen, Mika; Mishra, Pashupati P.; Wang, Xiaoling; Kaprio, Jaakko (2022)
      article
      <p>Abnormal blood pressure is strongly associated with risk of high-prevalence diseases, making the study of blood pressure a major public health challenge. Although biological mechanisms underlying hypertension at ...

    • Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples 

      Laajala, Essi; Halla-aho, Viivi; Grönroos, Toni; Kalim, Ubaid Ullah; Vähä-Mäkilä, Mari; Nurmio, Mirja; Kallionpää, Henna; Lietzén, Niina; Mykkänen, Juha; Rasool, Omid; Toppari, Jorma; Orešič, Matej; Knip, Mikael; Lund, Riikka; Lahesmaa, Riitta; Lähdesmäki, Harri (03 / 2022)
      article
      DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, ...

    • Polygenic prediction of body mass index and obesity through the life course and across ancestries 

      Smit, Roelof A.J.; Wade, Kaitlin H.; Hui, Qin; Arias, Joshua D.; Yin, Xianyong; Christiansen, Malene R.; Yengo, Loic; Preuss, Michael H.; Nakabuye, Mariam; Rocheleau, Ghislain; Graham, Sarah E.; Buchanan, Victoria L.; Chittoor, Geetha; Graff, Marielisa; Guindo-Martínez, Marta; Lu, Yingchang; Marouli, Eirini; Sakaue, Saori; Spracklen, Cassandra N.; Vedantam, Sailaja; Wilson, Emma P.; Chen, Shyh Huei; Ferreira, Teresa; Ji, Yingjie; Karaderi, Tugce; Lüll, Kreete; Machado, Moara; Malden, Deborah E.; Medina-Gomez, Carolina; Moore, Amy; Rüeger, Sina; Akiyama, Masato; Allison, Matthew A.; Alvarez, Marcus; Andersen, Mette K.; Appadurai, Vivek; Hansen, Thomas F.; Lyytikäinen, Leo Pekka; Mishra, Pashupati P.; Mononen, Nina; Mykkänen, Juha; Wang, Jun Sing; Hutri, Nina; Hyppönen, Elina; Kähönen, Mika; Kovacs, Peter; Lehtimäki, Terho; Nikus, Kjell; Tuomilehto, Jaakko; Kilpeläinen, Tuomas O. (09 / 2025)
      article
      Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East ...

    • Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study 

      Raitakari, Olli T.; Koskinen, Juhani S.; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Kartiosuo, Noora; Stenbacka, Sini; Lisinen, Irina; Loo, Britt Marie; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Laitinen, Tomi P.; Jokinen, Eero; Kaikkonen, Jari; Tossavainen, Päivi; Viikari, Jorma S.A. (09 / 2025)
      article
      Background and aims: Population based data are limited on the prevalence of carotid atherosclerosis across broad age-ranges from early childhood to old age. We aimed to determine the prevalence and determinants of carotid ...

    • Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature 

      Repo, Oskari; Juonala, Markus; Niinikoski, Harri; Rovio, Suvi; Mykkänen, Juha; Lagström, Hanna; Cheung, Carol Y.; Yang, Dawei; Vaahtoranta-Lehtonen, Hanna; Jula, Antti; Nevalainen, Jaakko; Rönnemaa, Tapani; Viikari, Jorma; Raitakari, Olli; Tapp, Robyn; Pahkala, Katja (01.09.2024)
      article
      Background and Aims Retinal microvasculature characteristics predict cardiovascular morbidity and mortality. This study investigated associations of lifelong cardiovascular risk factors and effects of dietary intervention ...

    • Sotetite-tutkimuspäivät tutkijan ja tutkimusryhmän näkökulmasta 

      Jylhä, Virpi; Mykkänen, Juha; Värri, Alpo (09.05.2022)
      editorial

    • Subclinical atherosclerosis in young adults predicting cardiovascular disease: The Cardiovascular Risk in Young Finns Study 

      Raitakari, Olli T.; Magnussen, Costan G.; Juonala, Markus; Kartiosuo, Noora; Pahkala, Katja; Rovio, Suvi; Koskinen, Juhani S.; Mykkänen, Juha; Laitinen, Tomi P.; Kähönen, Mika; Nuotio, Joel; Viikari, Jorma S.A. (2024)
      article
      Background and aims: Atherosclerosis is accompanied by pre-clinical vascular changes that can be detected using ultrasound imaging. We examined the value of such pre-clinical features in identifying young adults who are ...

    • Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia 

      Auvinen, Juha; Tapio, Joona; Karhunen, Ville; Kettunen, Johannes; Serpi, Raisa; Dimova, Elitsa Y.; Gill, Dipender; Soininen, Pasi; Tammelin, Tuija; Mykkänen, Juha; Puukka, Katri; Kähönen, Mika; Raitoharju, Emma; Lehtimäki, Terho; Ala-Korpela, Mika; Raitakari, Olli T.; Keinänen-Kiukaanniemi, Sirkka; Järvelin, Marjo Riitta; Koivunen, Peppi (2021)
      article
      Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower ...