"Kooner, Jaspal S." - Selaus tekijän mukaan TUNICRIS-julkaisut

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    • DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures 

      Gomez-Alonso, Monica del C.; Kretschmer, Anja; Wilson, Rory; Pfeiffer, Liliane; Karhunen, Ville; Seppälä, Ilkka; Zhang, Weihua; Mittelstraß, Kirstin; Wahl, Simone; Matias-Garcia, Pamela R.; Prokisch, Holger; Horn, Sacha; Meitinger, Thomas; Serrano-Garcia, Luis R.; Sebert, Sylvain; Raitakari, Olli; Loh, Marie; Rathmann, Wolfgang; Müller-Nurasyid, Martina; Herder, Christian; Roden, Michael; Hurme, Mikko; Jarvelin, Marjo Riitta; Ala-Korpela, Mika; Kooner, Jaspal S.; Peters, Annette; Lehtimäki, Terho; Chambers, John C.; Gieger, Christian; Kettunen, Johannes; Waldenberger, Melanie (2021)
      article
      Background: The discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation and ...

    • Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits 

      Keaton, Jacob M.; Kamali, Zoha; Xie, Tian; Vaez, Ahmad; Williams, Ariel; Goleva, Slavina B.; Ani, Alireza; Evangelou, Evangelos; Hellwege, Jacklyn N.; Yengo, Loic; Young, William J.; Traylor, Matthew; Giri, Ayush; Zheng, Zhili; Zeng, Jian; Chasman, Daniel I.; Morris, Andrew P.; Caulfield, Mark J.; Hwang, Shih Jen; Kooner, Jaspal S.; Conen, David; Attia, John R.; Morrison, Alanna C.; Loos, Ruth J.F.; Kristiansson, Kati; Schmidt, Reinhold; Hicks, Andrew A.; Pramstaller, Peter P.; Nelson, Christopher P.; Samani, Nilesh J.; Risch, Lorenz; Gyllensten, Ulf; Melander, Olle; Riese, Harriette; Wilson, James F.; Campbell, Harry; Rich, Stephen S.; Psaty, Bruce M.; Lu, Yingchang; Rotter, Jerome I.; Guo, Xiuqing; Rice, Kenneth M.; Vollenweider, Peter; Sundström, Johan; Langenberg, Claudia; Tobin, Martin D.; Giedraitis, Vilmantas; Luan, Jian'an; Tuomilehto, Jaakko; Lehtimäki, Terho (01.05.2024)
      article
      Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8) from the largest single-stage blood pressure (BP) ...

    • Genome-wide characterization of circulating metabolic biomarkers 

      Karjalainen, Minna K.; Karthikeyan, Savita; Oliver-Williams, Clare; Sliz, Eeva; Allara, Elias; Fung, Wing Tung; Surendran, Praveen; Zhang, Weihua; Jousilahti, Pekka; Kristiansson, Kati; Salomaa, Veikko; Goodwin, Matt; Hughes, David A.; Boehnke, Michael; Fernandes Silva, Lilian; Yin, Xianyong; Mahajan, Anubha; Neville, Matt J.; van Zuydam, Natalie R.; de Mutsert, Renée; Li-Gao, Ruifang; Mook-Kanamori, Dennis O.; Demirkan, Ayse; Liu, Jun; Noordam, Raymond; Trompet, Stella; Chen, Zhengming; Kartsonaki, Christiana; Li, Liming; Lin, Kuang; Hagenbeek, Fiona A.; Hottenga, Jouke Jan; Pool, René; Ikram, M. Arfan; van Meurs, Joyce; Haller, Toomas; Milaneschi, Yuri; Kähönen, Mika; Mishra, Pashupati P.; Joshi, Peter K.; Macdonald-Dunlop, Erin; Mangino, Massimo; Zierer, Jonas; Acar, Ilhan E.; Hoyng, Carel B.; Lechanteur, Yara T.E.; Franke, Lude; Kurilshikov, Alexander; Zhernakova, Alexandra; Beekman, Marian; van den Akker, Erik B.; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Gieger, Christian; Waldenberger, Melanie; Asselbergs, Folkert W.; Hayward, Caroline; Fu, Jingyuan; den Hollander, Anneke I.; Menni, Cristina; Spector, Tim D.; Wilson, James F.; Lehtimäki, Terho; Raitakari, Olli T.; Penninx, Brenda W.J.H.; Esko, Tonu; Walters, Robin G.; Jukema, J. Wouter; Sattar, Naveed; Ghanbari, Mohsen; Willems van Dijk, Ko; Karpe, Fredrik; McCarthy, Mark I.; Laakso, Markku; Järvelin, Marjo Riitta; Timpson, Nicholas J.; Perola, Markus; Kooner, Jaspal S.; Chambers, John C.; van Duijn, Cornelia; Slagboom, P. Eline; Boomsma, Dorret I.; Danesh, John; Ala-Korpela, Mika; Butterworth, Adam S.; Kettunen, Johannes (2024)
      article
      Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1–7. This detailed knowledge of the genetic determinants of systemic metabolism ...