"Koivunen, Jussi" - Selaus tekijän mukaan TUNICRIS-julkaisut

Viitteet 1-10 / 10

    • Blood-based tumor mutational burden as a biomarker in unresectable non-small cell lung cancer treated with chemoradiotherapy and durvalumab 

      Horndalsveen, Henrik; Haakensen, Vilde Drageset; Madebo, Tesfaye; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Koivunen, Jussi; Oselin, Kersti; Cicenas, Saulius; Helbekkmo, Nina; Aanerud, Marianne; Ahvonen, Jarkko; Silvoniemi, Maria; Bjaanæs, Maria Moksnes; Farooqi, Saima; Nebdal, Daniel; Dalsgaard, Astrid Marie; Danielsen, Britina Kjuul; Børve, Mari; Dalen, Tonje Sofie; Öjlert, Åsa Kristina; Helland, Åslaug (2025)
      article
      Introduction: Chemoradiotherapy followed by durvalumab is a potentially curative treatment for unresectable, locally advanced non-small cell lung cancer (NSCLC), but clinical outcomes remain highly variable. Identifying ...

    • Effect of Lung Cancer Screening, Smoking Cessation, and Cessation Smartphone App to Health-Related Quality of Life Among Heavy Smokers: Randomized Controlled Trial 

      Kurtti, Antti; Iivanainen, Sanna; Kaarteenaho, Riitta; Andersen, Heidi; Jekunen, Antti; Vasankari, Tuula; Koivunen, Jussi (2026)
      article
      Background: Lung cancer screening with low-dose computed tomography (LDCT) among heavy smokers can decrease lung cancer mortality. Smoking cessation intervention is recommended within the screening program; however, the ...

    • Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours 

      Mishra, Surbhi; Tejesvi, Mysore Vishakantegowda; Hekkala, Jenni; Turunen, Jenni; Kandikanti, Niyati; Kaisanlahti, Anna; Suokas, Marko; Leppä, Sirpa; Vihinen, Pia; Kuitunen, Hanne; Sunela, Kaisa; Koivunen, Jussi; Jukkola, Arja; Kalashnikov, Ilja; Auvinen, Päivi; Kääriäinen, Okko Sakari; Peñate Medina, T.; Peñate Medina, O.; Saarnio, Juha; Meriläinen, Sanna; Rautio, Tero; Aro, Raila; Häivälä, Reetta; Suojanen, Juho; Laine, Mikael; Erawijattari, Pande Putu; Lahti, Leo; Karihtala, Peeter; Ruuska, Terhi S.; Reunanen, Justus (2024)
      article
      Introduction: Gut microbiome–derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. The diverse ...

    • Gut microbiota-derived extracellular vesicles form a distinct entity from gut microbiota 

      Kaisanlahti, Anna; Turunen, Jenni; Hekkala, Jenni; Mishra, Surbhi; Karikka, Sonja; Amatya, Sajeen Bahadur; Paalanne, Niko; Kruger, Johanna; Portaankorva, Anne M.; Koivunen, Jussi; Jukkola, Arja; Vihinen, Pia; Auvinen, Päivi; Leppä, Sirpa; Karihtala, Peeter; Koivukangas, Vesa; Hukkanen, Janne; Vainio, Seppo; Samoylenko, Anatoliy; Bart, Genevieve; Lahti, Leo; Reunanen, Justus; Tejesvi, Mysore V.; Ruuska-Loewald, Terhi (2025)
      article
      Extracellular vesicles (EVs), nanoparticles secreted by both gram-negative and gram-positive bacteria, carry various biomolecules and cross biological barriers. Gut microbiota-derived EVs are currently being investigated ...

    • How does pulmonary function impact QoL in patients with locally advanced NSCLC treated with chemoradiotherapy and durvalumab? 

      Sommervoll, Frigg; Horndalsveen, Henrik; Sommervoll, Dag Einar; Koivunen, Jussi; Halvorsen, Tarje Onsøien; Grønberg, Bjørn Henning; Aanerud, Marianne; Cicenas, Saulius; Helbekkmo, Nina; Ahvonen, Jarkko; Silvoniemi, Maria; Barrera, Gina; Bjaanæs, Maria M.; Haakensen, Vilde D.; Öjlert, Åsa; Oselin, Kersti; Helland, Åslaug; Madebo, Tesfaye (2026)
      article
      Background: Impaired pulmonary function is common among patients with lung cancer and may negatively affect health-related quality of life (HRQoL). The primary objective of the present sub-study of the DART-trial was to ...

    • Impact of the COVID-19 pandemic on the quality of life of early breast cancer patients undergoing adjuvant chemotherapy: an observational, multicenter study 

      Tuomarila, Marie; Poikonen-Saksela, Paula; Kondylakis, Haridimos; Mattson, Johanna; Auvinen, Päivi; Jukkola, Arja; Kalashnikov, Ilja; Koivunen, Jussi; Kääriäinen, Okko Sakari; Sunela, Kaisa; Utriainen, Meri; Vihinen, Pia; Leppä, Sirpa; Karihtala, Peeter (08.10.2025)
      article
      BACKGROUND AND PURPOSE: We evaluated the impact of the coronavirus disease 2019 (COVID-19) pandemic on health-related quality of life (HRQoL) in early-stage breast cancer patients receiving adjuvant chemotherapy. PATIENTS ...

    • The metabolome of fecal extracellular vesicles in patients with malignant solid tumors 

      Mishra, Surbhi; Maltseva, Arina; Nieminen, Anni I.; Niku, Mikael; Karikka, Sonja; Hekkala, Jenni; Leppä, Sirpa; Vihinen, Pia; Sunela, Kaisa; Koivunen, Jussi; Jukkola, Arja; Kalashnikov, Ilja; Auvinen, Päivi; Kääriäinen, Okko Sakari; Saarnio, Juha; Meriläinen, Sanna; Rautio, Tero; Aro, Raila; Häivälä, Reetta; Karihtala, Peeter; Ruuska-Loewald, Terhi; Reunanen, Justus (2025)
      article
      Dysregulated metabolism, a hallmark of cancer, creates unique metabolic features that can be employed to elucidate cancer prognosis, personalized treatment, and therapeutic response. Metabolomics has emerged as a powerful ...

    • A national precision cancer medicine implementation initiative for Finland 

      Jalkanen, Katriina J.; Alanne, Erika; Iivanainen, Sanna; Kääriäinen, Okko Sakari; Tanner, Minna; Auranen, Annika; Koivunen, Jussi; Nykopp, Timo K.; Vihinen, Pia; Mustonen, Mika (23.05.2024)
      letter

    • Previous radiotherapy improves treatment responses and causes a trend toward longer time to progression among patients with immune checkpoint inhibitor-related adverse events 

      Jokimäki, Anna; Hietala, Henna; Lemma, Jasmiini; Karhapää, Hanna; Rintala, Anna; Kaikkonen, Jari Pekka; Sunela, Kaisa; Boman, Eva; Jukkola, Arja; Tiainen, Satu; Seppälä, Jan; Rönkä, Aino; Hakkarainen, Heikki; Kärnä, Aarno; Iivanainen, Sanna; Koivunen, Jussi; Auvinen, Päivi; Hernberg, Micaela; Kuusisto, Milla; Selander, Tuomas; Kuittinen, Outi (2023)
      article
      Background: Immune-related adverse events (irAEs) are frequently encountered by patients during immune checkpoint inhibitor (ICI) treatment and are associated with better treatment outcomes. The sequencing of radiotherapy ...

    • Systemic blockade of clever-1 elicits lymphocyte activation alongside checkpoint molecule downregulation in patients with solid tumors: Results from a phase I/II clinical trial 

      Virtakoivu, Reetta; Rannikko, Jenna H.; Viitala, Miro; Vaura, Felix; Takeda, Akira; Lönnberg, Tapio; Koivunen, Jussi; Jaakkola, Panu; Pasanen, Annika; Shetty, Shishir; De Jonge, Maja J.A.; Robbrecht, Debbie; Ma, Yuk Ting; Skyttä, Tanja; Minchom, Anna; Jalkanen, Sirpa; Karvonen, Matti K.; Mandelin, Jami; Bono, Petri; Hollmen, Maija (2021)
      article
      Purpose: Macrophages are critical in driving an immunosuppressive tumor microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents able to reprogram macrophages toward a proinflammatory state ...