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Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling

Mirzaie, Mehdi; Gholizadeh, Elham; Miettinen, Juho J.; Ianevski, Filipp; Ruokoranta, Tanja; Saarela, Jani; Manninen, Mikko; Miettinen, Susanna; Heckman, Caroline A.; Jafari, Mohieddin (2024)
article

Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A combination of drugs is required to effectively treat this disease. Computational models are critical ...