"Deary, Ian J." - Selaus tekijän mukaan TUNICRIS-julkaisut

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    • DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases 

      Wielscher, Matthias; Mandaviya, Pooja R.; Kuehnel, Brigitte; Joehanes, Roby; Mustafa, Rima; Robinson, Oliver; Zhang, Yan; Bodinier, Barbara; Walton, Esther; Mishra, Pashupati P.; Schlosser, Pascal; Wilson, Rory; Tsai, Pei Chien; Palaniswamy, Saranya; Marioni, Riccardo E.; Fiorito, Giovanni; Cugliari, Giovanni; Karhunen, Ville; Ghanbari, Mohsen; Psaty, Bruce M.; Loh, Marie; Bis, Joshua C.; Lehne, Benjamin; Sotoodehnia, Nona; Deary, Ian J.; Chadeau-Hyam, Marc; Brody, Jennifer A.; Cardona, Alexia; Selvin, Elizabeth; Smith, Alicia K.; Miller, Andrew H.; Torres, Mylin A.; Marouli, Eirini; Gào, Xin; van Meurs, Joyce B.J.; Graf-Schindler, Johanna; Rathmann, Wolfgang; Koenig, Wolfgang; Peters, Annette; Weninger, Wolfgang; Farlik, Matthias; Zhang, Tao; Chen, Wei; Xia, Yujing; Teumer, Alexander; Nauck, Matthias; Grabe, Hans J.; Lehtimäki, Terho; Hurme, Mikko A.; Kähönen, Mika (03.05.2022)
      article
      We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent ...

    • Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes 

      Chen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Díez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E.W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obón-Santacana, Mireia; Martín-Sánchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun Seog; Shin, Min Ho; Shin, Aesun; Ahn, Yoon Ok; Kim, Dong Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu Tang; Jia, Wei Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Böhm, Jan; Mecklin, Jukka Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hänninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Männistö, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellví-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D.P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J.M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bézieau, Stéphane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei (2024)
      article
      Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought ...

    • Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci 

      de las Fuentes, Lisa; Schwander, Karen L.; Brown, Michael R.; Bentley, Amy R.; Winkler, Thomas W.; Sung, Yun Ju; Munroe, Patricia B.; Miller, Clint L.; Aschard, Hugo; Aslibekyan, Stella; Bartz, Traci M.; Bielak, Lawrence F.; Chai, Jin Fang; Cheng, Ching Yu; Dorajoo, Rajkumar; Feitosa, Mary F.; Guo, Xiuqing; Hartwig, Fernando P.; Horimoto, Andrea; Kolčić, Ivana; Lim, Elise; Liu, Yongmei; Manning, Alisa K.; Marten, Jonathan; Musani, Solomon K.; Noordam, Raymond; Padmanabhan, Sandosh; Rankinen, Tuomo; Richard, Melissa A.; Ridker, Paul M.; Smith, Albert V.; Vojinovic, Dina; Zonderman, Alan B.; Alver, Maris; Boissel, Mathilde; Christensen, Kaare; Freedman, Barry I.; Gao, Chuan; Giulianini, Franco; Harris, Sarah E.; He, Meian; Hsu, Fang Chi; Kühnel, Brigitte; Laguzzi, Federica; Li, Xiaoyin; Lyytikäinen, Leo-Pekka; Nolte, Ilja M.; Poveda, Alaitz; Rauramaa, Rainer; Riaz, Muhammad; Robino, Antonietta; Sofer, Tamar; Takeuchi, Fumihiko; Tayo, Bamidele O.; van der Most, Peter J.; Verweij, Niek; Ware, Erin B.; Weiss, Stefan; Wen, Wanqing; Yanek, Lisa R.; Zhan, Yiqiang; Amin, Najaf; Arking, Dan E.; Ballantyne, Christie; Boerwinkle, Eric; Brody, Jennifer A.; Broeckel, Ulrich; Campbell, Archie; Canouil, Mickaël; Chai, Xiaoran; Chen, Yii Der Ida; Chen, Xu; Chitrala, Kumaraswamy Naidu; Concas, Maria Pina; de Faire, Ulf; de Mutsert, Renée; de Silva, H. Janaka; de Vries, Paul S.; Do, Ahn; Faul, Jessica D.; Fisher, Virginia; Floyd, James S.; Forrester, Terrence; Friedlander, Yechiel; Girotto, Giorgia; Gu, C. Charles; Hallmans, Göran; Heikkinen, Sami; Heng, Chew Kiat; Homuth, Georg; Hunt, Steven; Ikram, M. Arfan; Jacobs, David R.; Kavousi, Maryam; Khor, Chiea Chuen; Kilpeläinen, Tuomas O.; Koh, Woon Puay; Komulainen, Pirjo; Langefeld, Carl D.; Liang, Jingjing; Liu, Kiang; Liu, Jianjun; Lohman, Kurt; Mägi, Reedik; Manichaikul, Ani W.; McKenzie, Colin A.; Meitinger, Thomas; Milaneschi, Yuri; Nauck, Matthias; Nelson, Christopher P.; O’Connell, Jeffrey R.; Palmer, Nicholette D.; Pereira, Alexandre C.; Perls, Thomas; Peters, Annette; Polašek, Ozren; Raitakari, Olli T.; Rice, Kenneth; Rice, Treva K.; Rich, Stephen S.; Sabanayagam, Charumathi; Schreiner, Pamela J.; Shu, Xiao Ou; Sidney, Stephen; Sims, Mario; Smith, Jennifer A.; Starr, John M.; Strauch, Konstantin; Tai, E. Shyong; Taylor, Kent D.; Tsai, Michael Y.; Uitterlinden, André G.; van Heemst, Diana; Waldenberger, Melanie; Wang, Ya Xing; Wei, Wen Bin; Wilson, Gregory; Xuan, Deng; Yao, Jie; Yu, Caizheng; Yuan, Jian Min; Zhao, Wei; Becker, Diane M.; Bonnefond, Amélie; Bowden, Donald W.; Cooper, Richard S.; Deary, Ian J.; Divers, Jasmin; Esko, Tõnu; Franks, Paul W.; Froguel, Philippe; Gieger, Christian; Jonas, Jost B.; Kato, Norihiro; Lakka, Timo A.; Leander, Karin; Lehtimäki, Terho; Magnusson, Patrik K.E.; North, Kari E.; Ntalla, Ioanna; Penninx, Brenda; Samani, Nilesh J.; Snieder, Harold; Spedicati, Beatrice; van der Harst, Pim; Völzke, Henry; Wagenknecht, Lynne E.; Weir, David R.; Wojczynski, Mary K.; Wu, Tangchun; Zheng, Wei; Zhu, Xiaofeng; Bouchard, Claude; Chasman, Daniel I.; Evans, Michele K.; Fox, Ervin R.; Gudnason, Vilmundur; Hayward, Caroline; Horta, Bernardo L.; Kardia, Sharon L.R.; Krieger, Jose Eduardo; Mook-Kanamori, Dennis O.; Peyser, Patricia A.; Province, Michael M.; Psaty, Bruce M.; Rudan, Igor; Sim, Xueling; Smith, Blair H.; van Dam, Rob M.; van Duijn, Cornelia M.; Wong, Tien Yin; Arnett, Donna K.; Rao, Dabeeru C.; Gauderman, James; Liu, Ching Ti; Morrison, Alanna C.; Rotter, Jerome I.; Fornage, Myriam (2023)
      article
      Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of ...

    • Meta-analysis of epigenome-wide association studies of carotid intima-media thickness 

      Portilla-Fernández, Eliana; Hwang, Shih Jen; Wilson, Rory; Maddock, Jane; Hill, W. David; Teumer, Alexander; Mishra, Pashupati P.; Brody, Jennifer A.; Joehanes, Roby; Ligthart, Symen; Ghanbari, Mohsen; Kavousi, Maryam; Roks, Anton J.M.; Danser, A. H.Jan; Levy, Daniel; Peters, Annette; Ghasemi, Sahar; Schminke, Ulf; Dörr, Marcus; Grabe, Hans J.; Lehtimäki, Terho; Kähönen, Mika; Hurme, Mikko A.; Bartz, Traci M.; Sotoodehnia, Nona; Bis, Joshua C.; Thiery, Joachim; Koenig, Wolfgang; Ong, Ken K.; Bell, Jordana T.; Meisinger, Christine; Wardlaw, Joanna M.; Starr, John M.; Seissler, Jochen; Then, Cornelia; Rathmann, Wolfgang; Ikram, M. Arfan; Psaty, Bruce M.; Raitakari, Olli T.; Völzke, Henry; Deary, Ian J.; Wong, Andrew; Waldenberger, Melanie; O’Donnell, Christopher J.; Dehghan, Abbas (2021)
      article
      <p>Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide ...

    • Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure 

      Wang, Heming; Noordam, Raymond; Cade, Brian E.; Schwander, Karen; Winkler, Thomas W.; Lee, Jiwon; Sung, Yun Ju; Bentley, Amy R.; Manning, Alisa K.; Aschard, Hugues; Kilpeläinen, Tuomas O.; Ilkov, Marjan; Brown, Michael R.; Horimoto, Andrea R.; Richard, Melissa; Bartz, Traci M.; Vojinovic, Dina; Lim, Elise; Nierenberg, Jovia L.; Liu, Yongmei; Chitrala, Kumaraswamynaidu; Rankinen, Tuomo; Musani, Solomon K.; Franceschini, Nora; Rauramaa, Rainer; Alver, Maris; Zee, Phyllis C.; Harris, Sarah E.; van der Most, Peter J.; Nolte, Ilja M.; Munroe, Patricia B.; Palmer, Nicholette D.; Kühnel, Brigitte; Weiss, Stefan; Wen, Wanqing; Hall, Kelly A.; Lyytikäinen, Leo Pekka; O’Connell, Jeff; Eiriksdottir, Gudny; Launer, Lenore J.; de Vries, Paul S.; Arking, Dan E.; Chen, Han; Boerwinkle, Eric; Krieger, Jose E.; Schreiner, Pamela J.; Sidney, Stephen; Shikany, James M.; Rice, Kenneth; Chen, Yii Der Ida; Gharib, Sina A.; Bis, Joshua C.; Luik, Annemarie I.; Ikram, M. Arfan; Uitterlinden, André G.; Amin, Najaf; Xu, Hanfei; Levy, Daniel; He, Jiang; Lohman, Kurt K.; Zonderman, Alan B.; Rice, Treva K.; Sims, Mario; Wilson, Gregory; Sofer, Tamar; Rich, Stephen S.; Palmas, Walter; Yao, Jie; Guo, Xiuqing; Rotter, Jerome I.; Biermasz, Nienke R.; Mook-Kanamori, Dennis O.; Martin, Lisa W.; Barac, Ana; Wallace, Robert B.; Gottlieb, Daniel J.; Komulainen, Pirjo; Heikkinen, Sami; Mägi, Reedik; Milani, Lili; Metspalu, Andres; Starr, John M.; Milaneschi, Yuri; Waken, R. J.; Gao, Chuan; Waldenberger, Melanie; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Roenneberg, Till; Völker, Uwe; Dörr, Marcus; Shu, Xiao Ou; Mukherjee, Sutapa; Hillman, David R.; Kähönen, Mika; Wagenknecht, Lynne E.; Gieger, Christian; Grabe, Hans J.; Zheng, Wei; Palmer, Lyle J.; Lehtimäki, Terho; Gudnason, Vilmundur; Morrison, Alanna C.; Pereira, Alexandre C.; Fornage, Myriam; Psaty, Bruce M.; van Duijn, Cornelia M.; Liu, Ching Ti; Kelly, Tanika N.; Evans, Michele K.; Bouchard, Claude; Fox, Ervin R.; Kooperberg, Charles; Zhu, Xiaofeng; Lakka, Timo A.; Esko, Tõnu; North, Kari E.; Deary, Ian J.; Snieder, Harold; Penninx, Brenda W.J.H.; Gauderman, W. James; Rao, Dabeeru C.; Redline, Susan; van Heemst, Diana (15.04.2021)
      article
      <p>Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the ...

    • Variants associated with HHIP expression have sex-differential effects on lung function 

      Fawcett, Katherine A.; Wain, Louise V.; Obeidat, Ma'en; Melbourne, Carl; Shrine, Nick; Guyatt, Anna L.; John, Catherine; Luan, Jian'an; Richmond, Anne; Moksnes, Marta R.; Granell, Raquel; Weiss, Stefan; Imboden, Medea; May-Wilson, Sebastian; Hysi, Pirro; Boutin, Thibaud S.; Portas, Laura; Flexeder, Claudia; Harris, Sarah E.; Wang, Carol A.; Lyytikäinen, Leo Pekka; Palviainen, Teemu; Foong, Rachel E.; Keidel, Dirk; Minelli, Cosetta; Langenberg, Claudia; Bossé, Yohan; Van den Berge, Maarten; Sin, Don D.; Hao, Ke; Campbell, Archie; Porteous, David; Padmanabhan, Sandosh; Smith, Blair H.; Evans, David M.; Ring, Sue; Langhammer, Arnulf; Hveem, Kristian; Willer, Cristen; Ewert, Ralf; Stubbe, Beate; Pirastu, Nicola; Klaric, Lucija; Joshi, Peter K.; Patasova, Karina; Massimo, Mangino; Polasek, Ozren; Starr, John M.; Karrasch, Stefan; Strauch, Konstantin; Meitinger, Thomas; Rudan, Igor; Rantanen, Taina; Pietiläinen, Kirsi; Kähönen, Mika; Raitakari, Olli T.; Hall, Graham L.; Sly, Peter D.; Pennell, Craig E.; Kaprio, Jaakko; Lehtimäki, Terho; Vitart, Veronique; Deary, Ian J.; Jarvis, Debbie; Wilson, James F.; Spector, Tim; Probst-Hensch, Nicole; Wareham, Nicholas J.; Völzke, Henry; Henderson, John; Strachan, David P.; Brumpton, Ben M.; Hayward, Caroline; Hall, Ian P.; Tobin, Martin D. (2021)
      article
      <p>Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide ...