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    • Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma 

      Porsbjerg, Celeste M.; Townend, John; Bergeron, Celine; Christoff, George C.; Katsoulotos, Gregory P.; Larenas-Linnemann, Désirée; Tran, Trung N.; Al-Lehebi, Riyad; Bosnic-Anticevich, Sinthia Z.; Busby, John; Hew, Mark; Kostikas, Konstantinos; Papadopoulos, Nikolaos G.; Pfeffer, Paul E.; Popov, Todor A.; Rhee, Chin Kook; Sadatsafavi, Mohsen; Tsai, Ming Ju; Ulrik, Charlotte Suppli; Al-Ahmad, Mona; Altraja, Alan; Beastall, Aaron; Bulathsinhala, Lakmini; Carter, Victoria; Cosio, Borja G.; Fletton, Kirsty; Hansen, Susanne; Heaney, Liam G.; Hubbard, Richard B.; Kuna, Piotr; Murray, Ruth B.; Nagano, Tatsuya; Pini, Laura; Cano Rosales, Diana Jimena; Schleich, Florence; Wechsler, Michael E.; Amaral, Rita; Bourdin, Arnaud; Brusselle, Guy G.; Chen, Wenjia; Chung, Li Ping; Denton, Eve; Fonseca, Joao A.; Hoyte, Flavia; Jackson, David J.; Katial, Rohit; Kirenga, Bruce J.; Koh, Mariko Siyue; Ławkiedraj, Agnieszka; Lehtimäki, Lauri; Liew, Mei Fong; Mahboub, Bassam; Martin, Neil; Menzies-Gow, Andrew N.; Pang, Pee Hwee; Papaioannou, Andriana I.; Patel, Pujan H.; Perez-De-Llano, Luis; Peters, Matthew J.; Ricciardi, Luisa; Rodríguez-Cáceres, Bellanid; Solarte, Ivan; Tay, Tunn Ren; Torres-Duque, Carlos A.; Wang, Eileen; Zappa, Martina; Abisheganaden, John; Assing, Karin Dahl; Costello, Richard W.; Gibson, Peter G.; Heffler, Enrico; Máspero, Jorge; Nicola, Stefania; Perng, Diahn Warng; Puggioni, Francesca; Salvi, Sundeep; Sheu, Chau Chyun; Sirena, Concetta; Taillé, Camille; Tan, Tze Lee; Bjermer, Leif; Canonica, Giorgio Walter; Iwanaga, Takashi; Jiménez-Maldonado, Libardo; Taube, Christian; Brussino, Luisa; Price, David B. (2024)
      article
      Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical ...

    • Real-world biologics response and super-response in the International Severe Asthma Registry cohort 

      Denton, Eve; Hew, Mark; Peters, Matthew J.; Upham, John W.; Bulathsinhala, Lakmini; Tran, Trung N.; Martin, Neil; Bergeron, Celine; Al-Ahmad, Mona; Altraja, Alan; Larenas-Linnemann, Désirée; Murray, Ruth; Celis-Preciado, Carlos Andrés; Al-Lehebi, Riyad; Belhassen, Manon; Bhutani, Mohit; Bosnic-Anticevich, Sinthia Z.; Bourdin, Arnaud; Brusselle, Guy G.; Busby, John; Canonica, Giorgio Walter; Heffler, Enrico; Chapman, Kenneth R.; Charriot, Jérémy; Christoff, George C.; Chung, Li Ping; Cosio, Borja G.; Côté, Andréanne; Costello, Richard W.; Cushen, Breda; Fingleton, James; Fonseca, João A.; Gibson, Peter G.; Heaney, Liam G.; Huang, Erick Wan Chun; Iwanaga, Takashi; Jackson, David J.; Koh, Mariko Siyue; Lehtimäki, Lauri; Máspero, Jorge; Mahboub, Bassam; Menzies-Gow, Andrew N.; Mitchell, Patrick D.; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Perez-de-Llano, Luis; Perng, Diahn Warng; Pfeffer, Paul E.; Popov, Todor A.; Porsbjerg, Celeste M.; Rhee, Chin Kook; Roche, Nicolas; Sadatsafavi, Mohsen; Salvi, Sundeep; Schmid, Johannes Martin; Sheu, Chau-Chyun; Sirena, Concetta; Torres-Duque, Carlos A.; Salameh, Laila; Patel, Pujan H.; Ulrik, Charlotte Suppli; Wang, Eileen; Wechsler, Michael E.; Price, David B. (2024)
      article
      Background: Biologic asthma therapies reduce exacerbations and long-term oral corticosteroids (LTOCS) use in randomized controlled trials (RCTs); however, there are limited data on outcomes among patients ineligible for ...

    • Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach 

      Wang, Eileen; Henley, William; Larenas-Linnemann, Désirée; Bulathsinhala, Lakmini; Tran, Trung N.; Wechsler, Michael E.; Aaron, Shawn D.; Al-Ahmad, Mona; Al-Lehebi, Riyad; Altraja, Alan; Barker, Peter; Beastall, Aaron; Belevskiy, Andrey S.; Bergeron, Celine; Bjermer, Leif; Björnsdóttir, Unnur S.; Bosnic-Anticevich, Sinthia Z.; Bourdin, Arnaud; Brusselle, Guy G.; Busby, John; Canonica, Giorgio Walter; Carter, Victoria; Chapman, Kenneth R.; Chapman, Nicholas; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; Fingleton, James; Fonseca, João A.; Gaga, Mina; Gibson, Peter G.; Hansen, Susanne; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Horiguchi, Takahiko; Hoyte, Flavia; Hubbard, Richard B.; Iwanaga, Takashi; Jackson, David J.; Katial, Rohit; Koh, Mariko Siyue; Kostikas, Konstantinos; Kuna, Piotr; Lehmann, Sverre; Lehtimäki, Lauri; Louis, Renaud; Lúdvíksdóttir, Dóra; Lugogo, Njira; Mahboub, Bassam; Martin, Neil; Máspero, Jorge; Menzies-Gow, Andrew N.; Mohan, Arjun; Murray, Ruth B.; Nagano, Tatsuya; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Patel, Pujan H.; Perez-de-Llano, Luis; Perng, Diahn Warng; Peters, Matthew J.; Pfeffer, Paul E.; Pitrez, Paulo Márcio; Pleasants, Roy Alton; Popov, Todor A.; Porsbjerg, Celeste M.; Puggioni, Francesca; Quinton, Anna; Rhee, Chin Kook; Sadatsafavi, Mohsen; Salvi, Sundeep; Scioscia, Giulia; Sheu, Chau Chyun; Sirena, Concetta; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Tsai, Ming Ju; Tunsäter, Alf; Ulrik, Charlotte Suppli; Price, David B. (12 / 2025)
      article
      Background: Asthma with low levels of type 2 (T2) biomarkers is poorly understood. Objective: To characterize severe asthma phenotypes and compare changes in asthma outcomes from pre- to postbiologic treatment along a ...