"Aakula, Anna" - Selaus tekijän mukaan TUNICRIS-julkaisut

    • RAS and PP2A activities converge on epigenetic gene regulation 

      Aakula, Anna; Sharma, Mukund; Tabaro, Francesco; Nätkin, Reetta; Kamila, Jesse; Honkanen, Henrik; Schapira, Matthieu; Arrowsmith, Cheryl; Nykter, Matti; Westermarck, Jukka (2023)
      article
      RAS-mediated human cell transformation requires inhibition of the tumor suppressor protein phosphatase 2A (PP2A). However, the phosphoprotein targets and cellular processes in which RAS and PP2A activities converge in human ...
    • Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A 

      Pavic, Karolina; Gupta, Nikhil; Omella, Judit Domènech; Derua, Rita; Aakula, Anna; Huhtaniemi, Riikka; Määttä, Juha A.; Höfflin, Nico; Okkeri, Juha; Wang, Zhizhi; Kauko, Otto; Varjus, Roosa; Honkanen, Henrik; Abankwa, Daniel; Köhn, Maja; Hytönen, Vesa P.; Xu, Wenqing; Nilsson, Jakob; Page, Rebecca; Janssens, Veerle; Leitner, Alexander; Westermarck, Jukka (2023)
      article
      The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and ...