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Simulation of IP3 receptor function in cerebellar Purkinje cell dendritic spine: Importance of stochasticity
(2007)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: This thesis investigates calcium dynamics in cerebellar Purkinje cells. A special emphasis is put on the Purkinje cells dendritic spines where most of the synapses are formed. Transient rises in cytosolic ...
The 9p13.3 amplicon in prostate cancer
(2007)
Pro gradu -tutkielma
Pro gradu -tutkielma
Tutkimuksen tausta ja tavoitteet: Eturauhassyöpä on miesten yleisin syöpä Suomessa. Eturauhassyövän molekulaariset mekanismit ovat vielä epäselviä ja vain muutama todellinen kohdegeeni on löydetty. Tämän tutkimuksen ...
Cytosolic SH3-interactions of ADAM12-disintegrin-metalloprotease
(2007)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: ADAM proteins (a disintegrin and metalloprotease) are membrane proteins that consist of several functional domains. ADAM proteins are able to mediate cell adhesion through their disintegrin domain and selective ...
Expression of interleukin-10 family cytokines in rheumatoid arthritis
(2007)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and its expression is increased in rheumatoid arthritis (RA). A number of novel cytokines have been found recently, which have been designated ...
Effects of the androgen receptor overexpression in prostate cancer
(2007)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Prostate cancer is the leading cancer type in Finnish men. In about 30% of patients, the proceeding into a fatal hormone independent state involves the amplification and overexpression of the androgen ...