Haku

Background and aims: Celiac disease (CD) is a small intestine autoimmune disorder trigger by the ingestion of gluten containing cereals (wheat, barley and rye) in genetically predispose individuals (HLA-DQ2 or DQ8). The ...

Genetic variations that lead to changes in amino acid sequences have the ability to cause structural and functional changes of proteins. All such variations do not show phenotypic effects, so it is important to have ...

 Background and Aims: Aggregation has been shown to be an intrinsic property of many proteins including proteins not involved in amyloid diseases. The most common types of protein aggregates are amyloid fibrils and amorphous ...

Background: Adenosine deaminase (ADA, E.C.3.5.4.4) is an enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor ...

Post-translational modification (PTM) is a modification of a protein after its translation. This modification can occur either by the covalent addition of particular chemical groups or by enzymatic cleavage of peptide bond. ...

Background and aims: Gene and protein sequences are subject to variation upon reproduction where favorable alleles are expressed in further generations by positive selection and bad alleles are being eliminated by means ...

Background: T-cells are involved in many immune functions. Each function is carried out by specific sub-set of T-cells. All T-cell sub-types originate from one stem cell and the fate of each cell is dictated by its pattern ...

Background and aims:Protein Kinases having significant effects on signal transduction as well as most of the cellular processes, frequently causes diseases. A large number of disease-causing mutations have been recognized ...

Background and Aims: Carbonic anhydrases (CAs) occur abundantly in nature and are found in many organisms which participate in many biologically important processes. Among the -CA gene family, there are three homologues ...

Tutkimuksen tausta ja tavoitteet: Hiilihappoanhydraasi- proteiinit (carbonic anhydrases, CAs) toimivat kudoksien ja nesteiden pH:n säätelyssä katalysoiden CO2 + H2O   HCO3− + H+ reaktiota. Hiilihappoanhydraasit ovat ...