Haku

Background and aims: Chicken avidin is a homotetrameric β-barrel protein, whose affinity towards its natural ligand biotin is the strongest non-covalent protein-ligand interaction known. Functional avidin has four identical ...

Background Changes that occur in a nucleotide sequence of a gene are known as mutations. Mutations in general and single nucleotide polymorphisms (SNPs) in particular are the major driving forces of both genetic ...

ABSTRACT BACKGROUND: About 11% of human genes occur in divergent pairs such that both genes are located on opposite strands of DNA, and their immediate promoters are overlapping. The overlapping proximal promoter of both ...

Abstract Background and aims: Overlapping genes are adjacent genes whose coding sequences overlap partially or completely. They are abundant in the viruses and also present in archaea, prokaryotes and eukaryotes. Former ...

Background and aims: Signal peptides are central to biological processes in that they direct proteins to their proper destination after synthesis. If the signal sequence in a nascent was changed, the protein could end up ...

Prostate Cancer is a lethal disease characterized as progressive and possessing distinct molecular heterogeneity during its timespan. Vast number of abnormalities has been reported till now with number of somatic mutations ...

Background and Aims: Multiple Sequence Alignments (MSAs) help identify regions of similarity and dissimilarity between its constituent sequences, which is essential in understanding structural, functional and evolutionary ...

Background: Expression and protein-protein interaction data are often coupled in gene clustering, which has succeeded in many applications such as pathway discovery and function inference. However, asynchronous relations, ...