Haku
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The evolution and function of the minimal mitochondrial DNA replisome
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Analysis of regulated genes of BMP4 signaling in breast cancer cell lines
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aim: The role of bone morphogenetic proteins (BMP) 4 and 7 in primary breast cancer is peculiar as they are known to induce cell proliferation in some tumor cells and also to reduce tumor growth in some ...
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Recently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ...
Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Bruton tyrosine kinase (BTK) belong to the Tec family of non receptor tyrosine kinases that is a predominant cytoplasmic protein found in cells of humans that is responsible for B-lymphocyte development, differentiation, ...
Development of a Protein Conservation Analysis Pipeline and Application to Carbonic Anhydrase IV
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
*Background and Aims * Conservation is a hallmark of inherent valuable function. Computational analysis of conservation of each amino acid in a protein provides targets for future computational or experimental research. ...
The effect of pathogenic and neutral variants to the formation of nucleosome
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Chromatin contains enormous genetic information, with further folding and compaction processes owing to the special structure of nucleosomes, which ensure the genetic continuity of organisms. The ...
Identification of idh1 mutation-related gene signature of glioblastoma multiforme
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: Glioblastoma multiforme (GBM) is a type of commonly occurred malignant astrocytoma with an extremely poor prognosis. GBMs display a remarkable genetic variability, and it is essential to study the genomic ...
A Comparative Analysis of Thermodynamic Stability of Electron transport Chain Complex I Proteins and the Maximum Life Span of Host Organisms
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: "Mitochondrial theory of ageing" is an established theory which states that there is a correlation between Maximum Life Span (MLSP) of an organism and its mitochondrial free radical production. Here ...
Defining Lists of Conserved Amino Acid Residues in Alpha Carbonic Anhydrases
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Transcriptional regulation of bidirectional promoters: role of NF-Y
(2010)
Pro gradu -tutkielma
Pro gradu -tutkielma
ABSTRACT
BACKGROUND: About 11% of human genes occur in divergent pairs such that both genes are located on opposite strands of DNA, and their immediate promoters are overlapping. The overlapping proximal promoter of both ...