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The Effects of Inhibiting Mechanotransductive Cell Signaling Pathways in Human Bone Marrow Stromal Cells in 2D vs. 3D Culture
(2017)
Diplomityö
Diplomityö
Mechanotransduction is the process of mechanical information transfer between a cell and its surroundings into biochemical responses. Involved in mechanotransduction are several components: extracellular matrix (ECM), ...
Inhibition of fibroblast growth factor receptor in FGFR3:TACC3 fusion positive glioblastoma cells
(2017)
Diplomityö
Diplomityö
Glioblastoma multiforme is the most common of adult primary brain tumors. It is a highly aggressive form of diffuse gliomas and with current treatments median life expectancy of patients with glioblastoma is approximately ...
Up-Scaling of Microbial Co-Cultures
(2018)
Diplomityö
Diplomityö
Microbial fermentations are used to produce pharmaceuticals, chemicals, and fuels. Side product formation along with considerable losses in productivities and yields are often encountered in transition from laboratory- to ...
Maturation of human induced pluripotent stem cell-derived cardiomyocytes grown on polyethylene terephthalate textiles
(2018)
Diplomityö
Diplomityö
Human cardiomyocytes (CMs) have been difficult to obtain due to invasive heart biopsies and poor long-term survival of the cells, limiting their utilization in research of cardiac diseases. Human induced pluripotent stem ...
Evaluation and Development of Ultrasound Imaging Methods in Veterinary Clinic
(2018)
Diplomityö
Diplomityö
The aim of this Master’s Thesis was to evaluate and develope ultrasound imaging methods in veterinary clinics. Ultrasound is a beneficial imaging method in many ways and it is widely used in the field of veterinary medicine. ...
Enhancing the Structural Maturation and Attachment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes on Textile Surfaces
(2017)
Diplomityö
Diplomityö
Cardiovascular diseases are one of the leading causes of death in the world. In 2012 ~30% of all deaths were due to cardiovascular diseases. There is a need for new research, drug testing and treatment methods. Tissue ...
Lääkeaineiden kulkeutuminen ja poistuminen urbaanin hydrologisen kierron aikana
(2017)
Diplomityö
Diplomityö
Tässä työssä tavoitteena oli selvittää lääkeaineiden esiintyminen ja poistuminen urbaanin hydrologisen kierron aikana todellisessa pienen mittakaavan ympäristössä. Lääkeaineiden tutkimus jätevesissä ja ympäristössä on ...
Recombinant whole cell bacterial biosensors in the screening of natural extracts
(2018)
Diplomityö
Diplomityö
Natural extracts have been used in traditional medicine as remedies to treat for example inflammations. During the era of modern medicine, there has been a shift towards usage of synthetic substances. However, many bacteria ...
Reliability and Limitations of Compression Testing of Various Biomaterials
(2017)
Diplomityö
Diplomityö
Tissue-engineered scaffolds should mimic, as closely as possible, the one of the tissues to be replaced. Hence, mechanical tests are of paramount importance. However, as there are various biomaterials, with distinct ...
A screen for biofilm mutant Mycobacterium marinum
(2017)
Diplomityö
Diplomityö
Mycobacterium tuberculosis infects millions of people every year and in 2015 1.8 million people died from the disease. The main problem is that M. tuberculosis has a natural resistance to many antibiotics. Studying of M. ...