Haku
Viitteet 1-10 / 67
The impact of influenza A hemagglutinin glycosylations on the breadth of the humoral immune response
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Influenza A is a highly contagious respiratory virus whose surface protein hemagglutinin (HA) constantly obtains mutations at its five antigenic sites. These mutations occasionally lead to acquisition of new N-linked ...
Optimisation of qPCR-based methods for Giardia lamblia and Cryptosporidium spp. detection in human stool samples
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Millions of people die every year of intestinal parasite diseases. Two epidemiologically important parasites, Giardia lamblia and Cryptosporidium species (spp.) cause e.g. diarrhoea, vomiting and at ...
Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Bruton tyrosine kinase (BTK) belong to the Tec family of non receptor tyrosine kinases that is a predominant cytoplasmic protein found in cells of humans that is responsible for B-lymphocyte development, differentiation, ...
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Recently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ...
Cloning of UBAP2 and its role in prostate cancer
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Prostate cancer is a common malignancy affecting millions of men worldwide. The molecular mechanisms involved in prostate cancer are poorly understood. Genomic copy-number alterations are common in ...
Analysis of regulated genes of BMP4 signaling in breast cancer cell lines
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aim: The role of bone morphogenetic proteins (BMP) 4 and 7 in primary breast cancer is peculiar as they are known to induce cell proliferation in some tumor cells and also to reduce tumor growth in some ...
Role for heparanase in neural differentiation
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Adipose stem cells and structural composites in the engineering of vascularized bone tissue
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Neural specific knockdown of cytochrome c oxidase and rescue of deleterious phenotypes with alternative oxidase in Drosophila melanogaster
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
*Background and aims:* Defects in mitochondrial respiratory chain produce diseases commonly referred as mitochondrial diseases. Mitochondrial diseases most often affect tissues that have high energy demands, particularly ...