"Bioinformatiikka - Bioinformatics" - Selaus Tutkinto-ohjelman ja opintosuunnan mukaanOpinnäytteet - ylempi korkeakoulututkinto
Viitteet 1-20 / 34
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A Comparative Analysis of Thermodynamic Stability of Electron transport Chain Complex I Proteins and the Maximum Life Span of Host Organisms
(2014)
Pro gradu -tutkielmaBackground and Aims: "Mitochondrial theory of ageing" is an established theory which states that there is a correlation between Maximum Life Span (MLSP) of an organism and its mitochondrial free radical production. Here ... -
A comparison of the number of SNPs and mutations with synonymous (Ks) and nonsynonymous (Ka) substitution rates in human immunome
(2009)
Pro gradu -tutkielmaBackground Changes that occur in a nucleotide sequence of a gene are known as mutations. Mutations in general and single nucleotide polymorphisms (SNPs) in particular are the major driving forces of both genetic ... -
A joint finite mixture model for clustering genes from beta, Gaussian and Bernoulli distributed data
(2009)
Pro gradu -tutkielmaBackground: Expression and protein-protein interaction data are often coupled in gene clustering, which has succeeded in many applications such as pathway discovery and function inference. However, asynchronous relations, ... -
A molecular dynamics study of ligand binding in mutant avidins
(2009)
Pro gradu -tutkielmaBackground and aims: Chicken avidin is a homotetrameric β-barrel protein, whose affinity towards its natural ligand biotin is the strongest non-covalent protein-ligand interaction known. Functional avidin has four identical ... -
Aggregation prediction; A bioinformatics method for studying the effects of missense variations on pathogenicity
(2012)
Pro gradu -tutkielmaBackground and Aims: Aggregation has been shown to be an intrinsic property of many proteins including proteins not involved in amyloid diseases. The most common types of protein aggregates are amyloid fibrils and amorphous ... -
Analysis of carbonic anhydrase related proteins VIII, X, and XI
(2011)
Pro gradu -tutkielmaBackground and Aims: Carbonic anhydrases (CAs) occur abundantly in nature and are found in many organisms which participate in many biologically important processes. Among the -CA gene family, there are three homologues ... -
Analysis of evolutionary pressure and pathogenicity of missense variations
(2012)
Pro gradu -tutkielmaBackground and aims: Gene and protein sequences are subject to variation upon reproduction where favorable alleles are expressed in further generations by positive selection and bad alleles are being eliminated by means ... -
Analysis of missense mutations in adenosine deaminase using Pathogenic-Or-Not-Pipeline (PON-P)
(2010)
Pro gradu -tutkielmaBackground: Adenosine deaminase (ADA, E.C.3.5.4.4) is an enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor ... -
Analysis of nucleotide repeats at variation sites
(2012)
Pro gradu -tutkielmaAbstract Background and aims:Nucleotide repeats are sequences that are repeated two or more times in the genome. They are generally classified into two broad groups as tandem repeats or dispersed repeats. They can be found ... -
Analysis of regulated genes of BMP4 signaling in breast cancer cell lines
(2013)
Pro gradu -tutkielmaBackground and aim: The role of bone morphogenetic proteins (BMP) 4 and 7 in primary breast cancer is peculiar as they are known to induce cell proliferation in some tumor cells and also to reduce tumor growth in some ... -
Analysis of the Gene Expression Patterns of the Human Immunome
(2009)
Pro gradu -tutkielmaAbstract Background and aims: Genes and proteins involved in immune system are called immunome. A network is a system where nodes are connected to each other by edges. In gene network genes are nodes and tissues are edges, ... -
Analysis of variation site in post-translational modification
(2013)
Pro gradu -tutkielmaPost-translational modification (PTM) is a modification of a protein after its translation. This modification can occur either by the covalent addition of particular chemical groups or by enzymatic cleavage of peptide bond. ... -
Applying genome-wide approach to define the genetics of low-density lipoprotein oxidation in two large cohorts
(2013)
Pro gradu -tutkielmaBackground: Cardiovascular diseases (CVD) are the number one killer and cause of disability in today’s world. Oxidized low-density lipoprotein (oxLDL) is considered to be a key factor in the development of atherosclerosis ... -
Bioinformatic analysis of next-generation sequencing data
(2012)
Pro gradu -tutkielmaBackround and aims:In a recent linkage study involving 69 Finnish HPC (Hereditary prostate cancer) families, a novel prostate cancer susceptibility locus 2q37.3 was found (Cropp et al. 2011). In addition a signal from ... -
Characterization of Pathogenic mutations in Kinase domain
(2013)
Pro gradu -tutkielmaBackground and aims:Protein Kinases having significant effects on signal transduction as well as most of the cellular processes, frequently causes diseases. A large number of disease-causing mutations have been recognized ... -
Codon usage bias of the overlapping genes in microbial genomes
(2010)
Pro gradu -tutkielmaAbstract Background and aims: Overlapping genes are adjacent genes whose coding sequences overlap partially or completely. They are abundant in the viruses and also present in archaea, prokaryotes and eukaryotes. Former ... -
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielmaRecently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ... -
Defining Lists of Conserved Amino Acid Residues in Alpha Carbonic Anhydrases
(2014)
Pro gradu -tutkielma -
Development of a Protein Conservation Analysis Pipeline and Application to Carbonic Anhydrase IV
(2013)
Pro gradu -tutkielma*Background and Aims * Conservation is a hallmark of inherent valuable function. Computational analysis of conservation of each amino acid in a protein provides targets for future computational or experimental research. ... -
Feature selection for classification of single amino acid variations
(2012)
Pro gradu -tutkielmaGenetic variations that lead to changes in amino acid sequences have the ability to cause structural and functional changes of proteins. All such variations do not show phenotypic effects, so it is important to have ...
