"Bioinformatiikka - Bioinformatics" - Selaus Tutkinto-ohjelman ja opintosuunnan mukaanOpinnäytteet - ylempi korkeakoulututkinto
Viitteet 21-34 / 34
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Finding secretion signals in protein sequences
(2009)
Pro gradu -tutkielmaBackground and aims: Signal peptides are central to biological processes in that they direct proteins to their proper destination after synthesis. If the signal sequence in a nascent was changed, the protein could end up ... -
Genome wide scan for prostate cancer susceptibility genes
(2008)
Pro gradu -tutkielmaBackground and aims: Prostate cancer is the leading cancer type in Finnish men. It was suggested that 5% to 10% of incident cases are attributed to rare, highly penetrated alleles in single gene forms of disease. The aim ... -
Genome-Wide Comparison of Copy Number Variations in Finnish Familial Prostate and Breast Cancers
(2012)
Pro gradu -tutkielmaAbstract Background and aims: Prostate and breast cancers are the most prevalent types of cancer in all Western countries including Finland. For both cancer types, there is a “missing heritability” - the genetic defects ... -
Identification of genes involved in T-cell differentiation
(2013)
Pro gradu -tutkielmaBackground: T-cells are involved in many immune functions. Each function is carried out by specific sub-set of T-cells. All T-cell sub-types originate from one stem cell and the fate of each cell is dictated by its pattern ... -
Identification of idh1 mutation-related gene signature of glioblastoma multiforme
(2014)
Pro gradu -tutkielmaBackground: Glioblastoma multiforme (GBM) is a type of commonly occurred malignant astrocytoma with an extremely poor prognosis. GBMs display a remarkable genetic variability, and it is essential to study the genomic ... -
Mutational analysis of non-coding genome in prostate cancer using whole genome sequencing
(2014)
Pro gradu -tutkielmaProstate Cancer is a lethal disease characterized as progressive and possessing distinct molecular heterogeneity during its timespan. Vast number of abnormalities has been reported till now with number of somatic mutations ... -
Pentraxin -Carbonic anhydrase CA VI: A novel multidomain protein
(2012)
Pro gradu -tutkielmaTutkimuksen tausta ja tavoitteet: Hiilihappoanhydraasi- proteiinit (carbonic anhydrases, CAs) toimivat kudoksien ja nesteiden pH:n säätelyssä katalysoiden CO2 + H2O HCO3− + H+ reaktiota. Hiilihappoanhydraasit ovat ... -
Protein-ligand interactions and their computational analysis using bioinformatics tools
(2015)
Pro gradu -tutkielma -
Proteomics: A tool for better understanding of celiac disease
(2011)
Pro gradu -tutkielmaBackground and aims: Celiac disease (CD) is a small intestine autoimmune disorder trigger by the ingestion of gluten containing cereals (wheat, barley and rye) in genetically predispose individuals (HLA-DQ2 or DQ8). The ... -
Sequence Conservation Metrics: Implementation and Comparative Analysis
(2009)
Pro gradu -tutkielmaBackground and Aims: Multiple Sequence Alignments (MSAs) help identify regions of similarity and dissimilarity between its constituent sequences, which is essential in understanding structural, functional and evolutionary ... -
Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein
(2013)
Pro gradu -tutkielmaBruton tyrosine kinase (BTK) belong to the Tec family of non receptor tyrosine kinases that is a predominant cytoplasmic protein found in cells of humans that is responsible for B-lymphocyte development, differentiation, ... -
The effect of pathogenic and neutral variants to the formation of nucleosome
(2013)
Pro gradu -tutkielmaBackground and Aims: Chromatin contains enormous genetic information, with further folding and compaction processes owing to the special structure of nucleosomes, which ensure the genetic continuity of organisms. The ... -
The evolution and function of the minimal mitochondrial DNA replisome
(2014)
Pro gradu -tutkielma -
Transcriptional regulation of bidirectional promoters: role of NF-Y
(2010)
Pro gradu -tutkielmaABSTRACT BACKGROUND: About 11% of human genes occur in divergent pairs such that both genes are located on opposite strands of DNA, and their immediate promoters are overlapping. The overlapping proximal promoter of both ...
