"Yang, Runkuan" - Selaus tekijän mukaan Artikkelit
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Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
(2016)
articleEthyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species (ROS). Treatment with EP is able to ameliorate systemic inflammation and ... -
Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose
(2012)
articleIntroduction Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early ... -
High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
(2012)
articleBackground Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect ... -
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity
(2014)
articleBackground Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte ... -
Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity
(2011)
articleBackground Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration ...
