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Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

She, Qing-Bai; Gruvberger-Saal, Sofia K; Maurer, Matthew; Chen, Yilun; Jumppanen, Mervi; Su, Tao; Dendy, Meaghan; Ingar Lau, Ying Ka; Memeo, Lorenzo; Horlings, Hugo M; van de Vijver, Marc J; Isola, Jorma; Hibshoosh, Hanina; Rosen, Neal; Parsons, Ramon; Saal, Lao H (2016)
article

The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved ...