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JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-γ-Induced iNOS Expression and NO Production in Macrophages

Sareila, Outi; Korhonen, Riku; Kärpänniemi, Outi; Nieminen, Riina; Kankaanranta, Hannu; Moilanen, Eeva (2006)
article

In inflammation, inducible nitric oxide synthase (iNOS) produces nitric oxide (NO), which modulates inflammatory processes. We investigated the effects of Janus kinase (JAK) inhibitors, AG-490 and WHI-P154, on iNOS expression ...