"Kähönen, Mika" - Selaus tekijän mukaan Artikkelit
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A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
(2012)
articleSex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases ... -
A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
(2012)
articleIntroduction Circulating cell-free DNA (cf-DNA) is a useful indicator of cell death, and it can also be used to predict outcomes in various clinical disorders. Several innate immune mechanisms are known to be involved in ... -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(2016)
articleLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ... -
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
(2016)
articleBackground Chronological aging-associated changes in the human DNA methylome have been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites have been identified as aging-associated in multiple ... -
Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression
(2014)
articleMOTIVATION: A typical genome-wide association study searches for associations between single nucleotide polymorphisms (SNPs) and a univariate phenotype. However, there is a growing interest to investigate associations ...
