Artikkelit - Trepo

Viitteet 1-3 / 3

Down-Regulation of Tristetraprolin Expression Results in Enhanced IL-12 and MIP-2 Production and Reduced MIP-3α Synthesis in Activated Macrophages

Jalonen, Ulla; Nieminen, R; Vuolteenaho, Katriina; Kankaanranta, Hannu; Moilanen, Eeva (2006)
article

In inflammation, the post-transcriptional regulation of transiently expressed genes provides a potential therapeutic target. Tristetraprolin (TTP) is of the factors regulating decay of cytokine mRNAs. The aim of the present ...
Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

Kankaanranta, Hannu; Janka-Junttila, Mirkka; Ilmarinen-Salo, Pinja; Ito, Kazuhiro; Jalonen, Ulla; Ito, Misako; Adcock, Ian; Moilanen, Eeva; Zhang, Xianzhi (2010)
article

Background Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) ...
Inhibitors of Mitogen-Activated Protein Kinases Downregulate COX-2 Expression in Human Chondrocytes

Nieminen, Riina; Leinonen, Sari; Lahti, Aleksi; Vuolteenaho, Katriina; Jalonen, Ulla; Kankaanranta, Hannu; Goldring, Mary B; Moilanen, Eeva (2005)
article

Inducible prostaglandin synthase (cyclooxygenase-2, COX-2) is expressed in rheumatoid and osteoarthritic cartilage and produces high amounts of proinflammatory prostanoids in the joint. In the present study we investigated ...