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Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

Kankaanranta, Hannu; Janka-Junttila, Mirkka; Ilmarinen-Salo, Pinja; Ito, Kazuhiro; Jalonen, Ulla; Ito, Misako; Adcock, Ian; Moilanen, Eeva; Zhang, Xianzhi (2010)
article

Background Granulocytes are important in the pathogenesis of several inflammatory diseases. Apoptosis is pivotal in the resolution of inflammation. Apoptosis in malignant cells is induced by histone deacetylase (HDAC) ...
Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation.

Ilmarinen-Salo, Pinja; Moilanen, Eeva; Kinnula, Vuokko L; Kankaanranta, Hannu (2012)
article

Background Eosinophils are critically involved in the pathogenesis of asthma. Nitric oxide (NO) is produced in high amounts in asthmatic lungs and has an important role as a regulator of lung inflammation. NO was ...