"Aalto-Setälä, Katriina" - Selaus tekijän mukaan Artikkelit
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A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells
(2010)
articleBackground The growth of stem cells in in vitro conditions requires optimal balance between signals mediating cell survival, proliferation, and self-renewal. For clinical application of stem cells, the use of completely ... -
All Titanium Microelectrode Array for Field Potential Measurements from Neurons and Cardiomyocytes: A Feasibility Study
(2011)
articleAbstract: In this paper, we describe our all-titanium microelectrode array (tMEA) fabrication process and show that uncoated titanium microelectrodes are fully applicable to measuring field potentials (FPs) from neurons ... -
Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models
(2015)
articleCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal ... -
Cardiac Differentiation of Pluripotent Stem Cells
(2011)
articleThe ability of human pluripotent stem cells to differentiate towards the cardiac lineage has attracted significant interest, initially with a strong focus on regenerative medicine. The ultimate goal to repair the heart by ... -
Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes
(2013)
articleCardiac safety pharmacology requires in-vitro testing of all drug candidates before clinical trials in order to ensure they are screened for cardio-toxic effects which may result in severe arrhythmias. Micro-electrode ... -
Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations
(2012)
articleBackground Induced pluripotent stem cells (iPSC) provide means to study the pathophysiology of genetic disorders. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant inherited ion channel disorder ... -
Culture Conditions Affect Cardiac Differentiation Potential of Human Pluripotent Stem Cells
(2012)
articleHuman pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), are capable of differentiating into any cell type in the human body and thus can be used ... -
CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels
(2015)
articleBackground Orientation and the degree of isotropy are important in many biological systems such as the sarcomeres of cardiomyocytes and other fibrillar structures of the cytoskeleton. Image based analysis of such ... -
Geenitestit kardiologisessa diagnostiikassa
(2010)
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