Haku
Viitteet 1-10 / 10
Analysis of regulated genes of BMP4 signaling in breast cancer cell lines
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aim: The role of bone morphogenetic proteins (BMP) 4 and 7 in primary breast cancer is peculiar as they are known to induce cell proliferation in some tumor cells and also to reduce tumor growth in some ...
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Recently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ...
Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Bruton tyrosine kinase (BTK) belong to the Tec family of non receptor tyrosine kinases that is a predominant cytoplasmic protein found in cells of humans that is responsible for B-lymphocyte development, differentiation, ...
Pseudogenes and Gene Duplications Tell a Story of Evolutionary Fates of Animal Alpha Carbonic Anhydrases
(Tampere University Press, 2013)
Artikkeliväitöskirja
Artikkeliväitöskirja
Tässä väitöskirjassa on tutkittu hiilihappoanhydraaseja (CA), entsyymejä jotka muuttavat hiilidioksidia vetykarbonaatti-ioneiksi ja päin vastoin. Hiilihappoanhydraasit ovat tarpeellisia hengityksessä, happo-emästasapainon ...
Development of a Protein Conservation Analysis Pipeline and Application to Carbonic Anhydrase IV
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
*Background and Aims * Conservation is a hallmark of inherent valuable function. Computational analysis of conservation of each amino acid in a protein provides targets for future computational or experimental research. ...
The effect of pathogenic and neutral variants to the formation of nucleosome
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Chromatin contains enormous genetic information, with further folding and compaction processes owing to the special structure of nucleosomes, which ensure the genetic continuity of organisms. The ...
Analysis of variation site in post-translational modification
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Post-translational modification (PTM) is a modification of a protein after its translation. This modification can occur either by the covalent addition of particular chemical groups or by enzymatic cleavage of peptide bond. ...
Identification of genes involved in T-cell differentiation
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: T-cells are involved in many immune functions. Each function is carried out by specific sub-set of T-cells. All T-cell sub-types originate from one stem cell and the fate of each cell is dictated by its pattern ...
Characterization of Pathogenic mutations in Kinase domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims:Protein Kinases having significant effects on signal transduction as well as most of the cellular processes, frequently causes diseases. A large number of disease-causing mutations have been recognized ...
Applying genome-wide approach to define the genetics of low-density lipoprotein oxidation in two large cohorts
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: Cardiovascular diseases (CVD) are the number one killer and cause of disability in today’s world. Oxidized low-density lipoprotein (oxLDL) is considered to be a key factor in the development of atherosclerosis ...