Haku
Viitteet 41-50 / 61
Transcriptional analysis reveals gender-specific changes in the aging of the human immune system
(2013)
- article
Aging and gender have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is scant information about the effect of aging ...
Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro
(2013)
- article
Background
Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. We have previously shown that HDL does not protect LDL from oxidation in vitro, but is in ...
Information-Theoretic Analysis of the Dynamics of an Executable Biological Model
(2013)
- article
To facilitate analysis and understanding of biological systems, large-scale data are often integrated into models using a variety of mathematical and computational approaches. Such models describe the dynamics of the ...
Characterization of aberrant pathways across human cancers
(2013)
- article
Background
Cancer is a broad group of genetic diseases which account for millions of deaths worldwide each year. Cancers are classified by various clinical, pathological and molecular methods, but even within a ...
How to evaluate performance of prediction methods? Measures and their interpretation in variation effect analysis
(2012)
- article
Background
Prediction methods are increasingly used in biosciences to forecast diverse features and characteristics. Binary two-state classifiers are the most common applications. They are usually based on machine ...
Functional Characterization of the Infection-Inducible Peptide Edin in Drosophila melanogaster
(2012)
- article
Abstract
Drosophila is a well-established model organism for studying innate immunity because of its high resistance against microbial infections and lack of adaptive immunity. In addition, the immune signaling cascades ...
Identification of proprotein convertase substrates using genome-wide expression correlation analysis
(2011)
- article
Background
Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regulatory function in a wide variety of biological processes. PCSKs proteolytically process at a target sequence that contains basic ...
Long-term prognosis of breast cancer detected by mammography screening or other methods
(2011)
- article
Introduction
Previous studies on breast cancer have shown that patients whose tumors are detected by mammography screening have a more favorable survival. However, little is known about the long-term prognostic impact of ...
ETS1 Mediates MEK1/2-Dependent Overexpression of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Human Cancer Cells
(2011)
- article
EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the ...
Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1
(2012)
- article
Background
STAT1 is an essential transcription factor for interferon-γ-mediated gene responses. A distinct sumoylation consensus site (ψKxE) 702IKTE705 is localized in the C-terminal region of STAT1, where Lys703 is a ...