Haku
Viitteet 11-20 / 20
Analysis of variation site in post-translational modification
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Post-translational modification (PTM) is a modification of a protein after its translation. This modification can occur either by the covalent addition of particular chemical groups or by enzymatic cleavage of peptide bond. ...
Analysis of evolutionary pressure and pathogenicity of missense variations
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Gene and protein sequences are subject to variation upon reproduction where favorable alleles are expressed in further generations by positive selection and bad alleles are being eliminated by means ...
Identification of genes involved in T-cell differentiation
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: T-cells are involved in many immune functions. Each function is carried out by specific sub-set of T-cells. All T-cell sub-types originate from one stem cell and the fate of each cell is dictated by its pattern ...
Characterization of Pathogenic mutations in Kinase domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims:Protein Kinases having significant effects on signal transduction as well as most of the cellular processes, frequently causes diseases. A large number of disease-causing mutations have been recognized ...
Analysis of carbonic anhydrase related proteins VIII, X, and XI
(2011)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Carbonic anhydrases (CAs) occur abundantly in nature and are found in many organisms which participate in many biologically important processes. Among the -CA gene family, there are three homologues ...
Pentraxin -Carbonic anhydrase CA VI: A novel multidomain protein
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Tutkimuksen tausta ja tavoitteet: Hiilihappoanhydraasi- proteiinit (carbonic anhydrases, CAs) toimivat kudoksien ja nesteiden pH:n säätelyssä katalysoiden CO2 + H2O HCO3− + H+ reaktiota. Hiilihappoanhydraasit ovat ...
Analysis of nucleotide repeats at variation sites
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Abstract
Background and aims:Nucleotide repeats are sequences that are repeated two or more times in the genome. They are generally classified into two broad groups as tandem repeats or dispersed repeats. They can be found ...
Genome-Wide Comparison of Copy Number Variations in Finnish Familial Prostate and Breast Cancers
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Abstract
Background and aims: Prostate and breast cancers are the most prevalent types of cancer in all Western countries including Finland. For both cancer types, there is a “missing heritability” - the genetic defects ...
Bioinformatic analysis of next-generation sequencing data
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Backround and aims:In a recent linkage study involving 69 Finnish HPC (Hereditary prostate cancer) families, a novel prostate cancer susceptibility locus 2q37.3 was found (Cropp et al. 2011). In addition a signal from ...
Applying genome-wide approach to define the genetics of low-density lipoprotein oxidation in two large cohorts
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: Cardiovascular diseases (CVD) are the number one killer and cause of disability in today’s world. Oxidized low-density lipoprotein (oxLDL) is considered to be a key factor in the development of atherosclerosis ...