Haku
Viitteet 11-20 / 40
The effect of pathogenic and neutral variants to the formation of nucleosome
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Chromatin contains enormous genetic information, with further folding and compaction processes owing to the special structure of nucleosomes, which ensure the genetic continuity of organisms. The ...
Analysis of the Gene Expression Patterns of the Human Immunome
(2009)
Pro gradu -tutkielma
Pro gradu -tutkielma
Abstract
Background and aims: Genes and proteins involved in immune system are called immunome. A network is a system where nodes are connected to each other by edges. In gene network genes are nodes and tissues are edges, ...
Genome wide scan for prostate cancer susceptibility genes
(2008)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Prostate cancer is the leading cancer type in Finnish men. It was suggested that 5% to 10% of incident cases are attributed to rare, highly penetrated alleles in single gene forms of disease. The aim ...
Identification of idh1 mutation-related gene signature of glioblastoma multiforme
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background: Glioblastoma multiforme (GBM) is a type of commonly occurred malignant astrocytoma with an extremely poor prognosis. GBMs display a remarkable genetic variability, and it is essential to study the genomic ...
A Comparative Analysis of Thermodynamic Stability of Electron transport Chain Complex I Proteins and the Maximum Life Span of Host Organisms
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: "Mitochondrial theory of ageing" is an established theory which states that there is a correlation between Maximum Life Span (MLSP) of an organism and its mitochondrial free radical production. Here ...
A molecular dynamics study of ligand binding in mutant avidins
(2009)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Chicken avidin is a homotetrameric β-barrel protein, whose affinity towards its natural ligand biotin is the strongest non-covalent protein-ligand interaction known. Functional avidin has four identical ...
A comparison of the number of SNPs and mutations with synonymous (Ks) and nonsynonymous (Ka) substitution rates in human immunome
(2009)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background
Changes that occur in a nucleotide sequence of a gene are known as mutations. Mutations in general and single nucleotide polymorphisms (SNPs) in particular are the major driving forces of both genetic ...
Defining Lists of Conserved Amino Acid Residues in Alpha Carbonic Anhydrases
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Transcriptional regulation of bidirectional promoters: role of NF-Y
(2010)
Pro gradu -tutkielma
Pro gradu -tutkielma
ABSTRACT
BACKGROUND: About 11% of human genes occur in divergent pairs such that both genes are located on opposite strands of DNA, and their immediate promoters are overlapping. The overlapping proximal promoter of both ...
Codon usage bias of the overlapping genes in microbial genomes
(2010)
Pro gradu -tutkielma
Pro gradu -tutkielma
Abstract
Background and aims: Overlapping genes are adjacent genes whose coding sequences overlap partially or completely. They are abundant in the viruses and also present in archaea, prokaryotes and eukaryotes. Former ...