Viitteet 11-20 / 64
Improved renal cancer prognosis among users of drugs targeting renin-angiotensin system
Purpose: We explored renal cell cancer (RCC) survival among users of antihypertensive medication as hypertension is proposed to be a risk factor for RCC and ACE-inhibitors and angiotensin receptor blockers (ARBs) have been ...
Population-based randomized trial of screening for clinically significant prostate cancer ProScreen : a pilot study
Objectives: To evaluate the feasibility of a population-based screening trial using prostate-specific antigen (PSA), a kallikrein panel and multiparametric magnetic resonance imaging (MRI) aimed at minimizing overdiagnosis, ...
Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease
Prostate cancer (PrCa) is one of the most common cancers in men, but little is known about factors affecting its clinical outcomes. Genome-wide association studies have identified more than 170 germline susceptibility loci, ...
Centralized repeated resectability assessment of patients with colorectal liver metastases during first-line treatment : prospective study
BACKGROUND: Metastasectomy is probably underused in metastatic colorectal cancer. The aim of this study was to investigate the effect of centralized repeated assessment on resectability rate of liver metastases. METHODS: ...
Surgical and functional outcomes and survival following Colon Cancer surgery in the aged : a study protocol for a prospective, observational multicentre study
Background: The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older ...
Estimating the rate of overdiagnosis with prostate cancer screening : evidence from the Finnish component of the European Randomized Study of Screening for Prostate Cancer
PURPOSE: Screening for prostate cancer may have limited impact on decreasing prostate cancer-related mortality. A major disadvantage is overdiagnosis, whereby lesions are identified that would not have become evident during ...
Predictive risk factors of complications in reduction mammoplasty—analysis of three different pedicles
Background: Reduction mammoplasty can be performed in several different techniques. Understanding the complication profile and risk factors in different reduction methods can help in choosing a technique, which serves the ...
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
Background: Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic ...
Randomised double-blind phase 3 clinical study testing impact of atorvastatin on prostate cancer progression after initiation of androgen deprivation therapy : study protocol
INTRODUCTION: Blood cholesterol is likely a risk factor for prostate cancer prognosis and use of statins is associated with lowered risk of prostate cancer recurrence and progression. Furthermore, use of statins has been ...
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been ...