Haku
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PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
(2016)
- article
BACKGROUND:
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
Simulation of developing human neuronal cell networks
(2016)
- article
BACKGROUND:
Microelectrode array (MEA) is a widely used technique to study for example the functional properties of neuronal networks derived from human embryonic stem cells (hESC-NN). With hESC-NN, we can investigate the ...
Large ameloblastic fibro-odontoma in a 7-year-old girl with analysis of 108 cases
(2016)
- article
BACKGROUND:
Odontogenic tumors such as ameloblastic fibro-odontoma (AFO) are rare conditions in children and are often asymptomatic. AFOs are found by routine clinical and radiological examination or when they cause obvious ...
Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans
(2014)
- article
Background
Despite the high prevalence of parasitic infections, and their impact on global health and economy, the number of drugs available to treat them is extremely limited. As a result, the potential consequences ...
Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer
(2014)
- article
The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the ...
A novel chimeric avidin with increased thermal stability using DNA shuffling
(2014)
- article
Avidins are a family of proteins widely employed in biotechnology. We have previously shown that functional chimeric mutant proteins can be created from avidin and avidin-related protein 2 using a methodology combining ...
Trastuzumab emtansine: mechanisms of action and drug resistance
(2014)
- article
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that is effective and generally well tolerated when administered as a single agent to treat advanced breast cancer. Efficacy has now been demonstrated in randomized ...
Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer : statistical evaluation of epistasis
(2014)
- article
Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the ...
Expression Patterns and Subcellular Localization of Carbonic Anhydrases Are Developmentally Regulated during Tooth Formation
(2014)
- article
Abstract
Carbonic anhydrases (CAs) play fundamental roles in several physiological events, and emerging evidence points at their involvement in an array of disorders, including cancer. The expression of CAs in the ...