Haku
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Analysis of regulated genes of BMP4 signaling in breast cancer cell lines
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aim: The role of bone morphogenetic proteins (BMP) 4 and 7 in primary breast cancer is peculiar as they are known to induce cell proliferation in some tumor cells and also to reduce tumor growth in some ...
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Recently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ...
Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Bruton tyrosine kinase (BTK) belong to the Tec family of non receptor tyrosine kinases that is a predominant cytoplasmic protein found in cells of humans that is responsible for B-lymphocyte development, differentiation, ...
Development of a Protein Conservation Analysis Pipeline and Application to Carbonic Anhydrase IV
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
*Background and Aims * Conservation is a hallmark of inherent valuable function. Computational analysis of conservation of each amino acid in a protein provides targets for future computational or experimental research. ...
The effect of pathogenic and neutral variants to the formation of nucleosome
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Chromatin contains enormous genetic information, with further folding and compaction processes owing to the special structure of nucleosomes, which ensure the genetic continuity of organisms. The ...
Proteomics: A tool for better understanding of celiac disease
(2011)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Celiac disease (CD) is a small intestine autoimmune disorder trigger by the ingestion of gluten containing cereals (wheat, barley and rye) in genetically predispose individuals (HLA-DQ2 or DQ8). The ...
Feature selection for classification of single amino acid variations
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Genetic variations that lead to changes in amino acid sequences have the ability to cause structural and functional changes of proteins. All such variations do not show phenotypic effects, so it is important to have ...
Aggregation prediction; A bioinformatics method for studying the effects of missense variations on pathogenicity
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Aggregation has been shown to be an intrinsic property of many proteins including proteins not involved in amyloid diseases. The most common types of protein aggregates are amyloid fibrils and amorphous ...
Analysis of variation site in post-translational modification
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Post-translational modification (PTM) is a modification of a protein after its translation. This modification can occur either by the covalent addition of particular chemical groups or by enzymatic cleavage of peptide bond. ...
Analysis of evolutionary pressure and pathogenicity of missense variations
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Gene and protein sequences are subject to variation upon reproduction where favorable alleles are expressed in further generations by positive selection and bad alleles are being eliminated by means ...