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Computational analysis of prostate cancer tumor microenvironment
(2022)
Pro gradu -tutkielma
Pro gradu -tutkielma
Prostate cancer is one of the most frequently diagnosed cancers in men worldwide. If the cancer is detected at an early stage, the prognosis is usually good. However, some prostate cancers are more aggressive and develop ...
Smoking alters the DNA Methylation of the Olfactory Sensing System
(2019)
Syventävä työ
Syventävä työ
Smoking as a major risk factor for the general ill-health and chronic diseases affect numerous regulatory systems of the human body, which respond to the damage by altering the gene expression through the epigenetic ...
Spatial chromatin accessibility : a computational method for single cell ATAC-seq and spatial transcriptomics data integration
(2023)
Diplomityö
Diplomityö
Cell fate is largely determined by the intricate interplay of chromatin compression and gene expression regulation. Expression can be suppressed by tightly packing the chromatin or enhanced by unwinding the DNA strand in ...
Predicting Spatially Resolved Gene Expression Clusters from Prostate Cancer Tissue Images with Convolutional Neural Networks
(2024)
Kandidaatintyö
Kandidaatintyö
Gleason grading is the standard evaluation method of prostate cancer severity. However, analysis of prostate cancer’s gene expression can lead to a more accurate and deeper understanding of cancer. New technologies, such ...