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Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
(2015)
- article
Background
Changes in DNA methylation are among the mechanisms contributing to the ageing process. We sought to identify ageing-associated DNA methylation changes at single-CpG-site resolution in blood leukocytes and ...
The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6 -/- mouse model
(2014)
- article
Background
Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It is highly expressed in the salivary and mammary glands and secreted into saliva and milk. Although CA VI was first described ...
Mapping of the chromosomal amplification 1p21-22 in bladder cancer
(2014)
- article
Background
The aim of the study was to characterize a recurrent amplification at chromosomal region 1p21-22 in bladder cancer.
Methods
ArrayCGH (aCGH) was performed to identify DNA copy number variations in 7 clinical ...
Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models
(2015)
- article
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal ...
MiRNA Profiles in Lymphoblastoid Cell Lines of Finnish Prostate Cancer Families
(2015)
- article
BACKGROUND:
Heritable factors are evidently involved in prostate cancer (PrCa) carcinogenesis, but currently, genetic markers are not routinely used in screening or diagnostics of the disease. More precise information ...
DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells
(2015)
- article
Introduction
Diabetes Associated Protein in Insulin-sensitive Tissues (DAPIT) is a subunit of mitochondrial ATP synthase and has also been found to associate with the vacuolar H+-ATPase. Its expression is particularly ...
Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish
(2015)
- article
Carbonic anhydrase related proteins (CARPs) X and XI are highly conserved across species and are predominantly expressed in neural tissues. The biological role of these proteins is still an enigma. Ray-finned fish have ...
β carbonic anhydrase is required for female fertility in Drosophila melanogaster
(2015)
- article
Background
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous enzymes that catalyze the reversible hydration reaction of carbon dioxide. CAs are present as six structurally divergent enzyme families: α, β, γ, δ, ζ and ...
His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display
(2015)
- article
Abstract
In addition to vaccines, noninfectious virus-like particles (VLPs) that mimic the viral capsid show an attractive possibility of presenting immunogenic epitopes or targeting molecules on their surface. Here, ...