Haku
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Mutational analysis of non-coding genome in prostate cancer using whole genome sequencing
(2014)
Pro gradu -tutkielma
Pro gradu -tutkielma
Prostate Cancer is a lethal disease characterized as progressive and possessing distinct molecular heterogeneity during its timespan. Vast number of abnormalities has been reported till now with number of somatic mutations ...
Development of a tool for copy number analysis of cancer genomes using high throughput sequencing data
(2015)
Pro gradu -tutkielma
Pro gradu -tutkielma
Genomic copy number alterations (CNA) and loss of heterozygozity (LOH) are two types of genomic instabilities associated with cancer. Acquisition of these genomic instabilities affects the expression level of oncogenes and ...