Haku
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Optimisation of qPCR-based methods for Giardia lamblia and Cryptosporidium spp. detection in human stool samples
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Millions of people die every year of intestinal parasite diseases. Two epidemiologically important parasites, Giardia lamblia and Cryptosporidium species (spp.) cause e.g. diarrhoea, vomiting and at ...
Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis
(2013)
- article
All genomes require a system for preventing collisions between the machineries of DNA replication and transcription. We have investigated the roles in this process of two proteins of the mTERF (mitochondrial transcription ...
Analysis of 953 Human Proteins from a Mitochondrial HEK293 Fraction by Complexome Profiling
(2013)
- article
Complexome profiling is a novel technique which uses shotgun proteomics to establish protein migration profiles from fractionated blue native electrophoresis gels. Here we present a dataset of blue native electrophoresis ...
Cloning of UBAP2 and its role in prostate cancer
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Prostate cancer is a common malignancy affecting millions of men worldwide. The molecular mechanisms involved in prostate cancer are poorly understood. Genomic copy-number alterations are common in ...
Leukemia Prediction Using Sparse Logistic Regression
(2013)
- article
We describe a supervised prediction method for diagnosis of acute myeloid leukemia (AML) from patient samples based on flow cytometry measurements. We use a data driven approach with machine learning methods to train a ...
Copy Number Variants in the Kallikrein Gene Cluster
(2013)
- article
The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number ...
Gene Expression Profiles in Human and Mouse Primary Cells Provide New Insights into the Differential Actions of Vitamin D3 Metabolites
(2013)
- article
1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D3 (25(OH)D3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) broadened the ...
Analysis of regulated genes of BMP4 signaling in breast cancer cell lines
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aim: The role of bone morphogenetic proteins (BMP) 4 and 7 in primary breast cancer is peculiar as they are known to induce cell proliferation in some tumor cells and also to reduce tumor growth in some ...
Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain
(2013)
Pro gradu -tutkielma
Pro gradu -tutkielma
Recently, a significant number of studies regarding the activation mechanism of talin's vinculin binding site (VBS) have been published. Since the hydrophobic VBS is in natural talin buried inside the helix structure, a ...
SH2 and SH3 domain interactions and characterization of a novel protein POSH2
(Tampere University Press, 2013)
Artikkeliväitöskirja
Artikkeliväitöskirja
Domeenit ovat valkuaisaineiden eli proteiinien itsenäisiä yksiköitä, joilla on tietty rakenne ja toiminta. Domeenit säätelevät soluissa monia proteiinien välisiä vuorovaikutuksia, jotka ovat tärkeitä solunsisäisessä ...