Haku
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Feature selection for classification of single amino acid variations
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Genetic variations that lead to changes in amino acid sequences have the ability to cause structural and functional changes of proteins. All such variations do not show phenotypic effects, so it is important to have ...
Aggregation prediction; A bioinformatics method for studying the effects of missense variations on pathogenicity
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and Aims: Aggregation has been shown to be an intrinsic property of many proteins including proteins not involved in amyloid diseases. The most common types of protein aggregates are amyloid fibrils and amorphous ...
Analysis of evolutionary pressure and pathogenicity of missense variations
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Background and aims: Gene and protein sequences are subject to variation upon reproduction where favorable alleles are expressed in further generations by positive selection and bad alleles are being eliminated by means ...
Pentraxin -Carbonic anhydrase CA VI: A novel multidomain protein
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Tutkimuksen tausta ja tavoitteet: Hiilihappoanhydraasi- proteiinit (carbonic anhydrases, CAs) toimivat kudoksien ja nesteiden pH:n säätelyssä katalysoiden CO2 + H2O HCO3− + H+ reaktiota. Hiilihappoanhydraasit ovat ...
Analysis of nucleotide repeats at variation sites
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Abstract
Background and aims:Nucleotide repeats are sequences that are repeated two or more times in the genome. They are generally classified into two broad groups as tandem repeats or dispersed repeats. They can be found ...
Genome-Wide Comparison of Copy Number Variations in Finnish Familial Prostate and Breast Cancers
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Abstract
Background and aims: Prostate and breast cancers are the most prevalent types of cancer in all Western countries including Finland. For both cancer types, there is a “missing heritability” - the genetic defects ...
Bioinformatic analysis of next-generation sequencing data
(2012)
Pro gradu -tutkielma
Pro gradu -tutkielma
Backround and aims:In a recent linkage study involving 69 Finnish HPC (Hereditary prostate cancer) families, a novel prostate cancer susceptibility locus 2q37.3 was found (Cropp et al. 2011). In addition a signal from ...