Haku
Viitteet 1-10 / 27
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
(2014)
- article
Background
Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play ...
Chimeric Avidin – NMR Structure and Dynamics of a 56 kDa Homotetrameric Thermostable Protein
(2014)
- article
Chimeric avidin (ChiAVD) is a product of rational protein engineering remarkably resistant to heat and harsh conditions. In quest of the fundamentals behind factors affecting stability we have elucidated the solution NMR ...
The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6 -/- mouse model
(2014)
- article
Background
Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It is highly expressed in the salivary and mammary glands and secreted into saliva and milk. Although CA VI was first described ...
Mapping of the chromosomal amplification 1p21-22 in bladder cancer
(2014)
- article
Background
The aim of the study was to characterize a recurrent amplification at chromosomal region 1p21-22 in bladder cancer.
Methods
ArrayCGH (aCGH) was performed to identify DNA copy number variations in 7 clinical ...
Breast cancer risk in families with mutations in PALB2
(2014)
- article
BACKGROUND:
Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown.
METHODS:
We ...
Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication
(2014)
- article
Mitochondrial DNA (mtDNA) is organized in discrete protein-DNA complexes, nucleoids, that are usually considered to be mitochondrial-inner-membrane associated. Here we addressed the association of replication factors with ...
pH-dependent deformations of the energy landscape of avidin-like proteins investigated by single molecule force spectroscopy
(2014)
- article
Avidin and avidin-like proteins are widely used in numerous techniques since the avidin-biotin interaction is known to be very robust and reliable. Within this study, we investigated this bond at the molecular level under ...
Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study
(2014)
- article
BACKGROUND:
Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of ...
Prostate cancer mortality in areas with high and low prostate cancer incidence
(2014)
- article
BACKGROUND:
The effect of prostate-specific antigen (PSA) screening on prostate cancer mortality remains debated, despite evidence from randomized trials. We investigated the association between prostate cancer incidence, ...
Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients
(2014)
- article
Breast cancer brain metastases (BCBM) are detected with increasing incidence. In order to detect potential genes involved in BCBM, we first screened for genes down-regulated by methylation in cell lines with site-specific ...